Thermodynamic constants for tautomerism, hydration, and ionization of vitamin B6 compounds in water/dioxane.
Thermodynamic constants for tautomerism, hydration, and ionization of vitamin B6 compounds in water/dioxane.
复制标题
维生素 B6 化合物在水/二恶烷中的互变异构、水合和电离的热力学常数。
DOI：
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发表时间：
1988
影响因子：
4.8
通讯作者：
J. M. Sanchez
中科院分区：
文献类型：
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作者：
M. Cortijo;J. Llor;J. M. Sanchez
在25 ℃水/二氧六环混合物中测定了苯酚、吡啶、对硝基苯酚、水杨醛、4-吡啶醛、吡哆醇、3-羟基吡啶、5-脱氧吡哆醛、吡哆醛和吡哆醛5 ′-磷酸盐的宏观去质子化常数。许多的水合和互变异构常数和微观pK值，这些化合物也被测量在相同的条件下。这些值进行了讨论，参考哈米特和马歇尔的方程和一般方程，预测这些平衡常数在讨论中的媒体已经制定。这些发现的意义上的化学维生素B6和它的重要性，在研究维生素B6依赖酶的催化途径进行了讨论。
The macroscopic deprotonation constants of phenol, pyridine, p-nitrophenol, salicylaldehyde, 4-pyridinaldehyde, pyridoxine, 3-hydroxypyridine, 5-deoxypyridoxal, pyridoxal, and pyridoxal 5'-phosphate have been determined at 25 degrees C in water/dioxane mixtures. Many of the hydration and tautomeric constants and microscopic pK values of these compounds have also been measured under the same conditions. These values are discussed with reference to Hammett's and Marshall's equations and a general equation that predicts these equilibrium constants in the media under discussion has been formulated. The significance of these findings on the chemistry of vitamin B6 and its importance in the study of the catalytic pathways of vitamin B6-dependent enzymes are also discussed.