The end of microbiology.
The end of microbiology.
复制标题
微生物学的终结。
DOI：
10.1111/1462-2920.14240
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发表时间：
2018
影响因子：
5.1
通讯作者：
Scott Chimileski
中科院分区：
文献类型：
--
作者：
R. Kolter;Scott Chimileski
未来将终结微生物学…但事实并非如此。在某种程度上，我们希望我们的标题具有挑衅性，同时也让我们的读者停下来思考一下。因为在我们看来，也许这些“视觉”类型的文章的一个有用的目的应该是在读者中激发一些跳出常规的思考。我们很高兴成为肯·蒂米斯邀请的作者小组的一员，为本刊20周年庆祝活动提供简短的评论文章。我们真的能预测未来吗？绝对不是。事实上，我们中的一个（RK）在之前的尝试中有失败的记录。一个例子记录在近十年前的《环境微生物学报告》中，他预测儿科医生将使用局部益生菌来治疗复发性耳部和咽喉感染（Kolter, 2009）。我们还没到那一步，不过平心而论，文章指出，再过几十年，鉴于目前人们对益生菌的兴趣，我们可能还会及时到达那一步。然而，第二个例子是一个更明显的未能预测未来的例子。到目前为止，还没有人写过这个例子。1980年，作为一名新上任的博士后，RK是斯坦福大学唯一一个拥有合成短寡核苷酸专业知识的人（这项技术是他在拉霍亚从Agouron研究所的理查德·奥格登那里学到的）。因此，他被要求为一家新兴的湾区公司“应用生物合成”（Applied Biosynthesis）提供有关使用合成寡核苷酸的咨询。建造一台能在一夜之间合成数百甚至数千个寡核苷酸的机器有用吗？“一点也不！””他建议。他说，这么多寡头不可能有市场。考虑
The future will bring the end of microbiology... but not really. With our title we wanted, in part, to be provocative and also to make our readers stop and think for a bit. For it appeared to us that perhaps a useful purpose of these ‘vision’types of essays should be to provoke some out-of-the-box thinking among the readers. We are delighted to be part of the group of authors that Ken Timmis has invited to contribute short opinion pieces as a part of the celebration of the 20th anniversary of this journal.Can we actually predict the future? By no means. In fact, one of us (RK) has a proven track record at failing in prior attempts. One example is recorded on the pages of Environmental Microbiology Reports, nearly a decade ago, where he predicted that pediatricians were to be using topical probiotics to manage recurrent ear and throat infections (Kolter, 2009). We are not there yet, though in all fairness, the text stated that to be a couple of decades away and with all the current interest in probiotics, we might still get there in time. The second example, however, is a clearer case of failing to predict the future. This example has, up to now not been written about. As a newly minted postdoctoral fellow in 1980, RK was the sole person at Stanford with the expertise to synthesize short olignucleotides (a technique he had learned at La Jolla from Richard Ogden of the Agouron Institute). As such, he was asked to consult for a budding Bay Area company, Applied Biosynthesis, on matters related to the use of synthetic oligonucleotides. Would it be useful to construct a machine that could synthesize hundreds or even thousands of oligonucleotides overnight?‘Not at all!’he advised.‘There is no way there could be a market for that many oligos’. Consider
影响因子：
5.4
作者：
Lyons NA;Kolter R
通讯作者：
Kolter R