Validation of the accuracy of both right and left ventricular outflow volume determinations and semiautomated calculation of shunt volumes through atrial septal defects by digital color Doppler flow mapping in a chronic animal model.
Validation of the accuracy of both right and left ventricular outflow volume determinations and semiautomated calculation of shunt volumes through atrial septal defects by digital color Doppler flow mapping in a chronic animal model.
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在慢性动物模型中通过数字彩色多普勒血流图验证右心室和左心室流出量测定以及通过房间隔缺损的分流量半自动计算的准确性。
DOI：
10.1016/s0735-1097(99)00210-7
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发表时间：
1999
影响因子：
24
通讯作者：
Sahn,DJ
中科院分区：
文献类型：
--
作者：
Shiota,T;Jones,M;Aida,S;Chikada,M;Tsujino,H;El-Kadi,T;Sahn,DJ
目的：本研究的目的是使用一种新的半自动彩色多普勒血流计算方法（ACM）定量测量经手术建立的房间隔缺损（ASDs）慢性动物模型的分流流量。由于脉冲多普勒是繁琐的，往往不适合彩色流计算，新的方法，如ACM是感兴趣的。方法在本研究中，8只羊在手术产生asd后13至25周，在单独的开胸实验中研究了24种血液动力学状态。使用电磁（EM）流量探头和流量计提供参考流量，作为肺和主动脉流量（Qpand Qs）和分流流量（Qpminus Qs）。心外膜超声心动图成像左、右心室流出道（LVOT和RVOT）前向血流信号。ACM方法将空间和时间的彩色流速数据进行数字集成，以提供笔画体积。结果ACM法测得的左室流出道和RVOT流量与EM法测得的结果吻合较好（r = 0.96， LVOT平均差= 0.78±1.7 ml; r = 0.97， RVOT平均差= - 0.35±3.6 ml）。结果表明，ACM方法的分流流量和Qp/Qs与EM方法的分流流量和Qp/Qs吻合较好（分流流量r = 0.96，平均差值=−1.1±3.6 ml/beat, Qp/Qs r = 0.95，平均差值=−0.11±0.22）。本动物实验采用严格量化的分流流量，证明ACM方法可以半自动、无创地提供Qp/ Qp和分流测量。
OBJECTIVESThe aim of the present study was to quantitate shunt flow volumes through atrial septal defects (ASDs) in a chronic animal model with surgically created ASDs using a new semiautomated color Doppler flow calculation method (ACM).BACKGROUNDBecause pulsed Doppler is cumbersome and often inappropriate for color flow computation, new methods such as ACM are of interest.METHODSIn this study, 13 to 25 weeks after ASDs were surgically created in eight sheep, a total of 24 hemodynamic states were studied at a separate open chest experimental session. Electromagnetic (EM) flow probes and meters were used to provide reference flow volumes as the pulmonary and aortic flow volumes (Qpand Qs) and shunt flow volumes (Qpminus Qs). Epicardial echocardiographic studies were performed to image the left and right ventricular outflow tract (LVOT and RVOT) forward flow signals. The ACM method digitally integrated spatial and temporal color flow velocity data to provide stroke volumes.RESULTSLeft ventricular outflow tract and RVOT flow volumes obtained by the ACM method agreed well with those obtained by the EM method (r = 0.96, mean difference = 0.78 ± 1.7 ml for LVOT and r = 0.97, mean difference = −0.35 ± 3.6 ml for RVOT). As a result, shunt flow volumes and Qp/Qsby the ACM method agreed well with those obtained by the EM method (r = 0.96, mean difference = −1.1 ± 3.6 ml/beat for shunt volumes and r = 0.95, mean difference = −0.11 ± 0.22 for Qp/Qs).CONCLUSIONSThis animal study, using strictly quantified shunt flow volumes, demonstrated that the ACM method can provide Qp/Qsand shunt measurements semiautomatically and noninvasively.