Association between primary biliary cholangitis and osteoporosis: meta-analysis
Association between primary biliary cholangitis and osteoporosis: meta-analysis
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DOI：
10.1007/s10067-017-3844-x
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发表时间：
2017-11-01
影响因子：
3.4
通讯作者：
Sun, Lingyun
中科院分区：
文献类型：
--
作者：
Fan, Junyu;Wang, Qian;Sun, Lingyun
原发性胆汁性胆管炎（PBC，以前称为原发性胆汁性肝硬化）和骨质疏松症风险之间的关系仍然存在争议。本荟萃分析旨在全面分析PBC与骨质疏松症之间的关联。我们对PubMed、EMBASE和Web of Science进行了系统的文献检索。采用固定或随机效应模型评估PBC患者和正常对照组的骨密度（BMD）、骨质疏松率和骨折。共纳入8项研究（包括1643例PBC患者和10,921例对照）。PBC患者的相对危险度（RR）为2.79（95% CI 1.26至6.16）对于骨质疏松症的发展，下腰椎BMD（95% CI -0. 13至-0. 04，P = 0. 0002）、髋部BMD（95% CI -0. 13至-0. 03，P = 0. 002）和腰椎t评分（95% CI -1. 69至-1. 02，P <0. 00001）。PBC患者发生骨折的OR为1.86（95%CI 1.54 ~ 2.24，P < 0.00001）。总的来说，这项荟萃分析表明PBC患者更容易患骨质疏松症。鉴于现有文献有限，需要更好的设计和更大规模的初步研究来证实我们的结论。
The relationship between primary biliary cholangitis (PBC, previously termed primary biliary cirrhosis) and risks of osteoporosis remains controversial. This meta-analysis was designed to comprehensively analyze the association between PBC and osteoporosis. We conducted a systematic literature search of the PubMed, EMBASE, and Web of Science. Either fixed or random effects models were applied to assess bone mineral density (BMD), osteoporosis rates, and fractures in PBC patients and normal controls. A total of eight studies were included (including 1643 PBC patients and 10,921 controls). PBC patients had a relative risk (RR) of 2.79 (95% CI 1.26 to 6.16) for the development of osteoporosis, lower lumbar spine BMD (95% CI - 0.13 to - 0.04, P = 0.0002), hip BMD (95% CI - 0.13 to - 0.03, P = 0.002), and lumbar spine t score (95% CI - 1.69 to - 1.02, P < 0.00001) than controls. Moreover, PBC patients had an OR of 1.86 (95%CI 1.54 to 2.24, P < 0.00001) for the development of fractures. Collectively, this meta-analysis indicates that PBC patients were more likely to suffer from osteoporosis. Given the limited literature available, better designed and larger scale primary studies will be required to confirm our conclusion.