Oxidative stress in the newborn - A 30-year perspective
Oxidative stress in the newborn - A 30-year perspective
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DOI：
10.1159/000087586
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发表时间：
2005-01-01
期刊：
影响因子：
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通讯作者：
Saugstad, OD
中科院分区：
文献类型：
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作者：
Saugstad, OD
本文综述了“缺氧-复氧损伤”概念的发展。介绍了与新生儿氧化应激损伤相关的一些重要因素和机制的最新进展，包括谷胱甘肽的代谢、抗氧化剂、铁和一氧化氮的作用，以及这些因素如何影响新生儿的健康和疾病，并导致新生儿氧自由基病。新的见解如何高氧和缺氧可能会导致血管内皮生长因子与胰岛素样生长因子协同作用的早产儿视网膜病变的变化进行了简要总结。在新生儿中，炎症和氧化应激似乎是同一枚硬币的两面，它们都通过类似的机制部分地导致损伤。版权所有（C）2005 S. Karger AG，巴塞尔。
In this review the development of the concept 'hypoxia-reoxygenation injury' is outlined. An update of some important factors and mechanisms related to oxidative stress injury in newborn infants is presented, including the metabolism of glutathione, the role of antioxidants, iron and nitric oxide, and how these may influence health and disease in the newborn and contribute to 'oxygen radical disease of the newborn'. New insight into how hyperoxia and hypoxia may induce changes leading to retinopathy of prematurity by vascular endothelial growth factor acting in concert with insulin-like growth factor is briefly summarized. Inflammation and oxidative stress seem to be two sides of the same coin in newborn babies both contributing to injury partly through similar mechanisms. Copyright (C) 2005 S. Karger AG, Basel.