Diabetic retinopathy and OCT angiography: clinical findings and future perspectives.
Diabetic retinopathy and OCT angiography: clinical findings and future perspectives.
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DOI：
10.1186/s40942-017-0062-2
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发表时间：
2017
影响因子：
2.3
通讯作者：
Avila M
中科院分区：
文献类型：
--
作者：
de Barros Garcia JMB;Isaac DLC;Avila M
在糖尿病视网膜病变（DR）中，黄斑受累可表现为黄斑水肿或缺血。血管造影仍然是评价视网膜血管灌注和诊断黄斑缺血的金标准。然而，这是一种昂贵、耗时的技术，需要静脉穿刺，并且已有与荧光素注射相关的过敏反应和死亡报告，尽管这种情况很少见。光学相干断层扫描（OCT）提供了一种快速和非侵入性的方法来评估视网膜结构在微观水平。OCT血管造影允许通过运动对比成像对视网膜和脉络膜循环进行无创研究。分谱振幅去相关血管造影术结合OCT血管造影术，进一步了解视网膜和脉络膜血管疾病，允许视网膜微血管系统的评价和识别后续的疾病，包括DR。以前的研究使用OCT血管造影术已经证明，它可以证明DR的结果，如微动脉瘤，小动脉壁染色，视网膜新生血管，和视网膜内微血管异常。本文的目的是描述和讨论OCT血管造影的不同概念，以及其在DR和黄斑病变诊断中的作用。
In diabetic retinopathy (DR), macular involvement can present as either macular edema or ischemia. Fluorescein angiography remains the gold standard in the evaluation of retinal vascular perfusion and diagnosis of macular ischemia. However, it is a costly, time-consuming technique, it requires venipuncture, and reports of anaphylaxis and death related to fluorescein injections have been documented, despite their rarity. Optical coherence tomography (OCT) provides a fast and non-invasive method to assess retinal structures at a microscopic level. OCT angiography permits the noninvasive study of retinal and choroid circulation via motion contrast imaging. Split-spectrum amplitude decorrelation angiography combined with OCT angiography has furthered the understanding of retinal and choroidal vascular diseases, allowing the evaluation of retinal microvasculature and identification of subsequent disorders, including DR. Previous studies using OCT angiography have demonstrated that it may demonstrate DR findings such as microaneurysms, arteriolar wall staining, retinal neovascularization, and intraretinal microvascular abnormalities. The purpose of this article is to describe and discuss different concepts regarding OCT angiography, as well as its role in the diagnosis of DR and maculopathy.