Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus.
Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus.
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DOI：
10.1084/jem.149.5.1099
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发表时间：
1979-05-01
期刊：
影响因子：
--
通讯作者：
Dixon FJ
中科院分区：
文献类型：
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作者：
Izui S;McConahey PJ;Theofilopoulos AN;Dixon FJ
研究了内源性逆转录病毒gp 70作为狼疮样疾病发病机制的参与者，狼疮样疾病在四种小鼠（NZB、NZB x W MRL/1和雄性BXSB）中自发发展。来自这些菌株的血清含有重形式的gp 70，其在蔗糖密度梯度分析中的沉降速率从9 S到19 S变化，并且随着疾病的发作而出现，并且在整个病程中持续存在。免疫正常的小鼠品系在8-10个月的生命中不会快速生长沉积gp 70。重gp 70被抗IgG抗体或金黄色葡萄球菌蛋白A选择性吸收的事实表明它与抗体复合。这些gp 70 IC的发生率和数量随着所有狼疮菌株中疾病的进展而上升。提示IG复合重链gp 70可能参与了SLE小鼠肾小球肾炎的发病过程。
Endogenous retroviral gp70 was investigated as a participant in the pathogenesis of a lupus-like disease that spontaneously develops in four kinds of mice (NZB, NZB x W MRL/1, and male BXSB). Sera from these strains contain a heavy form of gp 70 that varies in sedimentation rates from 9S to 19S in sucrose density gradient analysis and appears with the onset of disease and persists throughout its course. Immunologically normal strains of mice do not develop rapidly sedimenting gp70 by 8-10 mo of life. The fact that the heavy gp70 is selectively absorbed with anti-IgG antibodies or with Staphylococcus aureus protein A suggests that it is complexed with antibodies. The incidence and quantities of these gp70 ICs rise with the progression of disease in all strains with lupus. These findings suggest that Ig- complexed heavy gp70 may be involved in the pathogenesis of glomerulonephritis of mice with SLE.