Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles.
Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles.
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DOI：
10.1021/jacsau.2c00453
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发表时间：
2022-12-26
期刊：
影响因子：
8
通讯作者：
Cabral, Joao T
中科院分区：
文献类型：
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作者：
Tyagi, Gunjan;Greenfield, Jake L;Jones, Beatrice E;Sharratt, William N;Khan, Kasim;Seddon, Dale;Malone, Lorna A;Cowieson, Nathan;Evans, Rachel C;Fuchter, Matthew J;Cabral, Joao T
采用小角中子散射和X射线散射（SANS/SAXS）及紫外-可见吸收光谱研究了一种基于十六烷基三甲基溴化铵（CTAB）的芳基偶氮吡唑类光表面活性剂（PS）在水溶液中的自组装及其与CTAB的混合胶束形成过程.在紫外光照射下，PS从E-PS（反式）光异构化为Z-PS（顺式），这将扁椭圆形胶束转化为具有较大壳厚度的较小的球形胶束。掺杂PS与CTAB导致在所有化学计量和条件下的混合胶束形成的调查;采用选择性氘代PS，散射长度密度和胶束的核和壳的尺寸的单调变化，观察到所有的对比。浓度和光照依赖性的E到Z的构型转变建立在两个净和混合胶束。脂质体染料释放测定建立了光表面活性剂在膜破裂时的增强功效，相对于纯CTAB，E-PS表现出荧光信号增加4倍，Z-PS表现出荧光信号增加10倍。我们的研究结果为广泛的基于CTAB的生物医学和材料应用的外部触发和调制铺平了道路。
The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV–vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the E to Z configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with E-PS exhibiting a 4-fold and Z-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.