Changes in estrogen receptor-α expression in hypothalamic dopaminergic neurons during proestrous prolactin surge
Changes in estrogen receptor-α expression in hypothalamic dopaminergic neurons during proestrous prolactin surge
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DOI：
10.1385/endo:20:1-2:131
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发表时间：
2003-02-01
期刊：
影响因子：
3.7
通讯作者：
Voogt, JL
中科院分区：
文献类型：
--
作者：
Hou, YP;Yang, SP;Voogt, JL
雌性大鼠在发情期由于雌二醇和黄体酮水平升高而产生催乳素（PRL）激增。多巴胺是下丘脑从垂体分泌PRL的主要抑制剂。采用双标记免疫细胞化学方法，研究了发情期PRL激增时弓形核（ARC）和心室周围核（PeVN）多巴胺能神经元雌激素受体- α (er - α)免疫反应的变化规律，并与发情期PRL水平持续较低时进行了比较。我们的研究结果表明，在发情期，80%的ARC多巴胺能神经元er - α也呈阳性，而在发情前期，这一比例明显下降。相比之下,
A surge of prolactin (PRL) occurs in female rats during proestrus in response to elevated estradiol and progesterone levels. Dopamine is the primary hypothalamic inhibitor of PRL secretion from the pituitary., Using double-label immunocytochemistry, we investigated the pattern of estrogen receptor-alpha (ER-alpha) immunoreactivity in dopaminergic neurons in the arcuate nucleus (ARC) and the periventricular nucleus (PeVN) during the proestrous PRL surge and compared it to that during diestrus, when PRL levels are constantly low. Our results showed that during diestrus >80% of dopaminergic neurons in the ARC were also positive for ER-alpha, and this colocalization percentage decreased significantly during proestrus. By contrast,