Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji
Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji
复制标题
DOI：
10.7554/elife.48460
复制
发表时间：
2020-01-28
期刊：
影响因子：
7.7
通讯作者：
Kucharski, Adam J.
中科院分区：
文献类型：
--
作者：
Henderson, Alasdair D.;Aubry, Maite;Kucharski, Adam J.
人们普遍认为，寨卡病毒（ZIKV）感染可提供长期保护，防止再次感染，防止寨卡病毒在以前受影响的地区重新出现数年。然而，寨卡病毒暴发后对寨卡病毒的长期免疫反应记录仍然很少。我们比较了法属波利尼西亚和斐济已知寨卡病毒暴发前后的八次血清学调查结果，包括横断面和纵向研究。我们发现有证据表明，在首次报告寨卡病毒传播后的两年内，这两个国家的血清患病率有所下降。这种下降集中在成人，而儿童的高血清阳性率持续存在。在斐济队列中，针对寨卡病毒的中和抗体滴度也显著下降，但针对同一时期流行的登革热病毒的中和抗体滴度没有下降。
It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.