WNT-mediated Modulation of Bone Metabolism: Implications for WNT Targeting to Treat Extraskeletal Disorders.
WNT-mediated Modulation of Bone Metabolism: Implications for WNT Targeting to Treat Extraskeletal Disorders.
复制标题
DOI：
10.1177/0192623317738170
复制
发表时间：
2017-10
影响因子：
1.5
通讯作者：
Robling AG
中科院分区：
文献类型：
--
作者：
Bullock WA;Robling AG
WNT信号通路参与细胞和组织功能，控制多种过程，如体轴模式、细胞增殖、分化和寿命。可以参与或修饰WNT信号的分子列表很长，这使得该途径成为细胞生物学中最复杂的途径之一。在骨组织中，WNT信号是骨骼正常发育所必需的，人类在该级联的各种成分中的突变揭示了可以用来改善骨骼健康的药物靶向。特别是，编码WNT信号抑制剂sclerostin或WNT共受体LRP5的基因突变，突出了在低骨量患者中总结这些作用的潜在治疗价值。由于WNT在几乎所有组织中都具有多种作用，因此该领域的一个持续挑战是选择性地修饰目标组织中的WNT成分。
The WNT signaling pathway is involved in cellular and tissue functions that control such diverse processes as body axis patterning, cellular proliferation, differentiation, and lifespan. The long list of molecules that can participate or modify WNT signaling makes this pathway one of the most complex in cell biology. In bone tissue, WNT signaling is required for proper skeletal development, and human mutations in various components of the cascade have revealed insights into pharmacologic targeting that can be harnessed to improve skeletal health. In particular, mutations in genes that code for the WNT signaling inhibitor sclerostin or the WNT co-receptor LRP5 have highlighted the potential therapeutic value of recapitulating those effects in patients with low bone mass. A constant challenge in this area is selectively modifying WNT components in the tissue of interest, as WNT has manifold effects in nearly every tissue.
登录
查看更多内容
影响因子：
11.2
作者：
Zhang Y;Morris JP 4th;Yan W;Schofield HK;Gurney A;Simeone DM;Millar SE;Hoey T;Hebrok M;Pasca di Magliano M
通讯作者：
Pasca di Magliano M
影响因子：
5.8
作者：
Gardner, JC;van Bezooijen, RL;Papapoulos, SE
通讯作者：
Papapoulos, SE
影响因子：
4.1
作者：
Niziolek, Paul J.;Farmer, Takeisha L.;Robling, Alexander G.
通讯作者：
Robling, Alexander G.
DOI：
10.1111/cts.12420
发表时间：
2016-12
期刊：
Clinical and translational science
影响因子：
--
作者：
Singh P;Rong H;Gordi T;Bosley J;Bhattacharya I
通讯作者：
Bhattacharya I
影响因子：
9.8
作者：
Van Wesenbeeck, L;Cleiren, E;Van Hul, W
通讯作者：
Van Hul, W