Spatial encoding in primate hippocampus during free navigation
Spatial encoding in primate hippocampus during free navigation
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DOI：
10.1371/journal.pbio.3000546
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发表时间：
2019-12-01
期刊：
影响因子：
9.8
通讯作者：
Miller, Cory T.
中科院分区：
文献类型：
--
作者：
Courellis, Hristos S.;Nummela, Samuel U.;Miller, Cory T.
海马体包含两种神经信号定位细胞和θ振荡，它们对空间导航有贡献。虽然它们的互补关系已经在啮齿类动物中很好地建立起来，但它们在自由航行过程中在灵长类动物大脑中的各自贡献仍然不清楚。在这里，我们记录了自由移动的绒猴海马体中的神经活动，因为它们自然地探索了空间环境，以更明确地研究这个问题。我们报告的地方细胞在绒猴海马在自由航行表现出显着的相似之处，类似的神经元在其他哺乳动物物种。虽然θ振荡在绒猴海马体中普遍存在，但其活动模式与其他类群明显不同。这种局部场电位振荡发生在短的回合（约0.4秒），而不是连续的，既没有显着调制的运动，也没有一贯耦合到位置细胞的活动。这些研究结果表明，在自由航行的灵长类动物海马的位置细胞的活动和θ振荡之间的关系有很大的不同，从啮齿动物和绘画一个有趣的比较图片的神经基础的空间导航哺乳动物。
The hippocampus comprises two neural signals-place cells and theta oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neural activity in the hippocampus of freely moving marmosets as they naturally explored a spatial environment to more explicitly investigate this issue. We report place cells in marmoset hippocampus during free navigation that exhibit remarkable parallels to analogous neurons in other mammalian species. Although theta oscillations were prevalent in the marmoset hippocampus, the patterns of activity were notably different than in other taxa. This local field potential oscillation occurred in short bouts (approximately .4 s)-rather than continuously-and was neither significantly modulated by locomotion nor consistently coupled to place-cell activity. These findings suggest that the relationship between place-cell activity and theta oscillations in primate hippocampus during free navigation differs substantially from rodents and paint an intriguing comparative picture regarding the neural basis of spatial navigation across mammals.