Analysis of ventilator associated pneumonia (VAP) studies in Egyptian University Hospitals
Analysis of ventilator associated pneumonia (VAP) studies in Egyptian University Hospitals
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DOI：
10.1016/j.ejcdt.2013.04.008
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发表时间：
2013-01-01
影响因子：
0.1
通讯作者：
Abd Elhafez, Sayed Ahmad
中科院分区：
文献类型：
--
作者：
Fathy, Amal;Abdelhafeez, Rasha;Abd Elhafez, Sayed Ahmad
背景资料：呼吸机相关性肺炎（VAP）是一种由多种病原体引起的动态疾病，与发病率和死亡率相关。目的：本研究分析了埃及大学医院近10年来对VAP的研究，以描述VAP作为机械通气并发症的严重程度，并探讨其预测因素和最常见的致病微生物。为了识别相关的已发表研究，我们检索了过去10年在埃及发表的医学文献，使用中线PubMed和Google Scholar，其中全文文章已下载。我们还搜索了论文讨论，并通过（注册）在埃及大学图书馆联盟的网站访问的最高理事会的网站上的埃及University.Results：大多数的37项研究进行了分析，有关的危险因素，致病微生物，发病率。最常见的风险因素是白细胞减少症、血小板减少症、高CRP、代谢性酸中毒、经鼻气管插管、再次插管、既往抗生素使用、ICU环境污染（缺乏感染控制措施）、抗酸剂和H2阻滞剂使用、皮质类固醇使用和昏迷。主要致病菌为产气假单胞菌、克雷伯菌、大肠埃希菌、金黄色葡萄球菌、不动杆菌、念珠菌和变形杆菌。结论：建立大规模多中心全国性研究，探讨VAP的发病率、所有可能的危险因素（无论是可预防的还是不可预防的）、致病菌、VAP死亡率及其经济学意义是非常重要的。(C)2013年埃及胸部疾病和结核病学会。由爱思唯尔公司制作和主持
Background: Ventilator associated pneumonia (VAP) is a dynamic disease caused by a wide spectrum of pathogens and associated with morbidity and mortality.Purpose: The study concerned with an analysis of VAP studies done in Egyptian University Hospitals in the last 10 years to describe the magnitude of the problem of VAP as a complication of mechanical ventilation, and to explore its predictors and most common causative organisms.Methods: To identify relevant published studies we searched the medical literature for articles done in Egypt published during the past 10 years, using midline PubMed and Google scholar, where the full text articles were downloaded. We also searched the thesis discussed and passed (Registered) at the website of the Egyptian Universities libraries consortium visiting the website of the supreme council of Egyptian Universities.Results: Most of the 37 studies on which analysis were done were concerned with the risk factors, causative organisms, and incidence. The most common risk factors were leukopenia, thrombocytopenia, high CRP, metabolic acidosis, nasal endotracheal intubation, re-intubation, prior antibiotic use, and contaminated ICU environment with lack of infection control measures, use of antacids and H2 blocker, corticosteroids use, and coma. The most common causative organisms were Pseudomonas aerogenosa, Klebsiella, Escherichia coli, Staphylococcus aureus, Acinetobacter, Candida and Proteus.Conclusion: It is important to establish large-scale multi center national studies to explore incidence of VAP, all possible risk factors (whether preventable or non preventable), causative organisms, and mortality due to VAP and its economic aspect. (C) 2013 The Egyptian Society of Chest Diseases and Tuberculosis. Production and hosting by Elsevier B.V.