Predictors and longitudinal course of cognitive functioning in schizophrenia spectrum disorders, 10 years after baseline: The OPUS study
Predictors and longitudinal course of cognitive functioning in schizophrenia spectrum disorders, 10 years after baseline: The OPUS study
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DOI：
10.1016/j.schres.2016.03.025
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发表时间：
2016-08-01
影响因子：
4.5
通讯作者：
Nordentoft, Merete
中科院分区：
文献类型：
--
作者：
Bergh, Sara;Hjorthoj, Carsten;Nordentoft, Merete
背景资料：由于认知功能（CF）和功能结局之间存在相关性，因此确定精神分裂症谱系障碍认知功能长期进程的基线预测因子非常重要。确定CF是否保持稳定或变化过程中的疾病是另一个问题的interests.Methods：参与者从丹麦OPUS试验，年龄18-45岁，基线ICD-10精神分裂症谱诊断，进行了评估，在基线的精神病理学，社会和职业功能，和认知功能5（N = 298）和10年（N= 322）后基线。对10年CF的潜在基线预测因素进行单变量和多变量回归分析。此外，5和10年之间的后续coordination.Findings：CF受损的基线预测因子CF 10年后，包括男性性别，失业，不良的病前成就和发病年龄晚之间的变化进行了评估。完成高中学业并接受早期干预治疗与更好的CF相关。在单变量分析中，年龄、与父母一起长大、家庭和朋友数量、主要照顾者教育、病前社会功能、阴性症状、GAF（症状、功能）和药物滥用与CF相关。非参与者通常遭受更严重的功能障碍。纵向上，阴性症状的改善与处理速度和执行功能的改善相关。症状评分一般随着时间的推移而改善，而所有认知测试的分数保持stabil.Conclusion：目前的研究确定了几个强大的基线特征和10年的认知结果之间的关联。其他几个变量与10年认知结果一致。此外，我们发现CF随时间推移而稳定的证据。(C)© 2016 Elsevier B. V.版权所有。
Background: Identifying baseline predictors of the long-term course of cognitive functioning in schizophrenia spectrum disorders is important because of associations between cognitive functioning (CF) and functional outcome. Determining whether CF remains stable or change during the course of illness is another matter of interest.Methods: Participants from The Danish OPUS Trial, aged 18-45 years, with a baseline ICD-10 schizophrenia spectrum diagnosis, were assessed on psychopathology, social and vocational functioning at baseline, and cognitive functioning 5 (N = 298) and 10 years (N= 322) after baseline. Uni- and multi-variable regression analyses of potential baseline predictors of 10-year CF were performed. Also, changes in CF and symptomatology between 5 and 10 years of follow-up were assessed.Findings: Baseline predictors of impaired CF after 10 years included male gender, unemployment, poor premorbid achievement and later age of onset. Having finished high school and receiving early intervention treatment was associated with better CF. Age, growing up with both parents, number of family and friends, primary caregivers education, premorbid social function, negative symptoms, GAF (symptoms, function) and substance abuse, were associated with CF in univariable analyses. Non-participants generally suffered from more severe dysfunction. Longitudinally, amelioration in negative symptoms was associated with improved speed of processing and executive functions. Symptom scores generally improved with time, while scores for all cognitive tests remained stable.Conclusion: The current study identifies several robust associations between baseline characteristics and 10-year cognitive outcome. Several other variables were univariably associated with 10-year cognitive outcome. Also, we found evidence for stability of CF over time. (C) 2016 Elsevier B.V. All rights reserved.