ELECTRON MICROSCOPIC ALTERATIONS IN THE RAT HYPOPHYSIS AFTER SCALDING.
ELECTRON MICROSCOPIC ALTERATIONS IN THE RAT HYPOPHYSIS AFTER SCALDING.
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烫伤后大鼠脑垂体的电子显微镜变化。
DOI：
10.1002/aja.1001140105
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
E. Rennels
中科院分区：
文献类型：
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作者：
E. Rennels
我们实验室之前的研究表明，在大鼠接受标准烫伤后的12小时内，垂体储存的促肾上腺皮质激素（ACTH）损失超过一半（Timmer, 1960）。由于ACTH产生和储存的细胞位点仍然是垂体细胞生理学的一个未解决的方面，因此用电子显微镜研究烧伤动物的垂体腺是很有兴趣的。我们认为电镜下可能会发现一些变化，这些变化可能与应激诱导的ACTH分泌有关，也可能与初始分泌后ACTH合成增高有关。在之前的光镜研究中（Rennels, 1960），我们报道了垂体前叶细胞的以下变化：(1)有丝分裂中腺细胞数量显著但短暂的增加，(2)所有实质细胞的大小普遍减小，在应激后12小时变得最明显，(3)在应激后12和24小时嗜酸细胞的细胞质嗜碱性细胞增加。在初步报告中（Rennels， 1960年，1961年），我们描述了热应激后大鼠垂体的某些电镜变化。本报告扩展并记录了这些较早的调查结果。
Previous studies in our laboratory have shown that within 12 hours after subjecting rats to a standardized scald there is a loss of more than one-half of the pituitary store of ACTH (adrenocorticotrophic hormone),(Timmer,'60). Since the cellular locus of ACTH production and storage has remained an unresolved facet of pituitary cytophysiology, it was of interest to study the pituitary glands of burned animals with the electron microscope. It was reasoned that some electron microscopic changes might be found which could be related to the stress-induced outpouring of ACTH or to the heightened synthesis of this hormone which follows the initial discharge. In previous studies on this problem with the light microscope (Rennels,'60), we reported the following changes in cells of the anterior pituitary:(1) a marked but transient increase in the number of glandular cells in mitosis,(2) a general reduction in the size of all parenchymal cells which becomes most marked at 12 hours after stress, and (3) an increase at 12 and 24 hours after stress in cytoplasmic basophilia of the acidophiles. In preliminary reports (Rennels,'60,'61), we have described certain electron microscopic changes in the pituitary of the rat after thermal stress. The present report extends and documents these earlier findings.