Soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel biomarker for large-artery atherosclerotic stroke
Soluble lectin-like oxidized low-density lipoprotein receptor-1 as a novel biomarker for large-artery atherosclerotic stroke
复制标题
采用人工传输线和双面平行带状线的小型化4:1不等威尔金森功率分配器
DOI：
10.1155/2017/6751694
复制
发表时间：
2017-01-01
影响因子：
2.2
通讯作者：
Shao, Bei
中科院分区：
文献类型：
--
作者：
Huang, Wensi;Li, Qian;Shao, Bei
提出了一种基于微带人工传输线的4：1不等威尔金森功分器。对于ATL，采用了一系列曲折线电感器、平行板电容器和叉指电容器。所设计的功分器由三个ATL组成，并提出了一种利用ATL和双面平行带状线（DSPSL）技术设计高特性阻抗线路的方法。用这种方法可以实现150 Ω以上的高特性阻抗微带线，这是传统传输线由于导体宽度太窄而难以实现的。制作的4：1不等功率分配器具有良好的工作性能，占地55.3 mm × 37.8 mm，这是只有约40%的面积相比，传统的在0.9 GHz的。背景：血清可溶性凝集素样氧化低密度脂蛋白受体1（sLOX-1）已被证明与动脉粥样硬化在内皮细胞的进展。我们试图评估基线血清sLOX-1水平是否与大动脉粥样硬化（LAA）卒中的存在和短期功能结局相关。研究方法：该研究招募了241名受试者，包括148名LAA亚型急性缺血性卒中患者和93名非卒中对照。在入院后24 h内收集临床和实验室数据，包括血清sLOX-1浓度，并通过美国国立卫生研究院卒中量表评分评估LAA卒中患者的严重程度。3个月后采用改良兰金量表评定功能预后。sLOX-1水平与3个月时功能结局的相关性通过多元Logistic回归模型进行分析。结果如下：左心耳卒中患者的sLOX-1血清水平显著高于正常对照组（2.48 +/- 0.93 ng/ml对比对照组的2.22 +/- 0.79 ng/ml，t = 2.301，p = 0.022）。预后良好患者的血清sLOX-1水平显著低于预后不良患者（2.39 +/- 0.94 ng/ml vs. 2.77 +/- 0.84 ng/ml，p = 0.032）。在调整潜在混杂因素后，sLOX-1仍然是功能结局的独立预测因子，调整后OR为3.39（95%CI，1.61-7.11，p = 0.001）。结论：左心耳缺血性卒中患者血清sLOX-1水平较高，是左心耳缺血性卒中患者功能预后的独立预测因子。
A 4 : 1 unequal Wilkinson power divider using microstrip artificial transmission lines (ATLs) is proposed. For the ATL, a series of meandered-line inductors, parallel-plate capacitors, and interdigital capacitors are employed. The designed power divider is composed of three ATLs, and a method has been proposed using technology of ATLs and double-sided parallel-strip lines (DSPSLs) to design line of high characteristic impedance. Microstrip line with very high characteristic impedance of over 150 Omega has been achieved by this method, which cannot be easily achieved by conventional transmission lines because of comparably thin conductor width. The fabricated 4 : 1 unequal power divider has good operational performance and occupies 55.3 mm x 37.8 mm, which is only about 40% of area compared to a conventional one at 0.9 GHz.Background: Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been shown associated with the progression of atherosclerosis in endothelial cells. We sought to assess whether the baseline serum sLOX-1 levels are correlated with the presence and short-term functional outcome of large-artery atherosclerotic (LAA) stroke. Methods: The study recruited 241 subjects, including 148 consecutive patients with acute ischemic stroke with the subtype of LAA and 93 non-stroke controls. Clinical and laboratory data, including serum concentration of sLOX-1, were collected within 24h of admission, and the severity of LAA stroke patients was evaluated by National Institutes of Health Stroke Scale score. And functional outcome was assessed by modified Rankin Scale three months after stroke. The association between sLOX-1 level and the functional outcome at three months was analyzed by multiple logistic regression models. Results: Serum levels of sLOX-1 in the LAA stroke patients were significantly higher as compared to normal controls (2.48 +/- 0.93 ng/ml vs. 2.22 +/- 0.79 ng/ml in the controls, t = 2.301, p = 0.022). The levels of serum sLOX-1 in patients with good outcome were significantly lower than those with poor outcome (2.39 +/- 0.94 ng/ml vs. 2.77 +/- 0.84 ng/ml, p = 0.032). After adjusting for potential confounders, sLOX-1 was still an independent predictor for the function outcome with an adjusted OR of 3.39 (95% CI, 1.61-7.11, p = 0.001). Conclusions: The serum sLOX-1 level was higher in patients with LAA stroke, and it was an independent predictor of functional outcome in patients with LAA ischemic stroke.