Transhepatic Therapies for Metastatic Uveal Melanoma
Transhepatic Therapies for Metastatic Uveal Melanoma
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DOI：
10.1055/s-0033-1333652
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发表时间：
2013-03-01
影响因子：
1.4
通讯作者：
Sato, Takami
中科院分区：
文献类型：
--
作者：
Eschelman, David J.;Gonsalves, Carin F.;Sato, Takami
尽管原发肿瘤已成功治疗，但葡萄膜黑色素瘤仍有转移至肝脏的倾向。由于这些肿瘤具有很强的侵袭性，预后很差。由于全身治疗相对无效，并且患者生存与肝脏疾病控制相关，因此局部治疗提供了延长生存的方法。我们回顾了治疗葡萄膜黑色素瘤肝转移的各种技术，包括化疗栓塞、免疫栓塞、放射栓塞、动脉福莫司汀输注和肝灌注。
Despite successful treatment of the primary tumor, uveal melanoma has a propensity to metastasize to the liver. Prognosis is poor due to the very aggressive nature of these tumors. Because systemic therapies are relatively ineffective and patient survival correlates to disease control in the liver, locoregional therapies provide a means of prolonging survival. We review various techniques including chemoembolization, immunoembolization, radioembolization, arterial fotemustine infusion, and hepatic perfusion for the treatment of liver metastases from uveal melanoma.