Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.
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DOI：
10.1371/journal.pone.0087688
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shafer WM
中科院分区：
文献类型：
--
作者：
Zughaier SM;Kandler JL;Shafer WM
Neisseria gonorrhoeae is a strict human pathogen that causes the sexually transmitted infection termed gonorrhea. The gonococcus can survive extracellularly and intracellularly, but in both environments the bacteria must acquire iron from host proteins for survival. However, upon infection the host uses a defensive response by limiting the bioavailability of iron by a number of mechanisms including the enhanced expression of hepcidin, the master iron-regulating hormone, which reduces iron uptake from the gut and retains iron in macrophages. The host also secretes the antibacterial protein NGAL, which sequesters bacterial siderophores and therefore inhibits bacterial growth. To learn whether intracellular gonococci can subvert this defensive response, we examined expression of host genes that encode proteins involved in modulating levels of intracellular iron. We found that N. gonorrhoeae can survive in association (tightly adherent and intracellular) with monocytes and macrophages and upregulates a panel of its iron-responsive genes in this environment. We also found that gonococcal infection of human monocytes or murine macrophages resulted in the upregulation of hepcidin, NGAL, and NRAMP1 as well as downregulation of the expression of the gene encoding the short chain 3-hydroxybutyrate dehydrogenase (BDH2); BDH2 catalyzes the production of the mammalian siderophore 2,5-DHBA involved in chelating and detoxifying iron. Based on these findings, we propose that N. gonorrhoeae can subvert the iron-limiting innate immune defenses to facilitate iron acquisition and intracellular survival.
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影响因子：
3.1
作者：
Hollander, Aimee;Mercante, Alexandra Dubon;Cornelissen, Cynthia Nau
通讯作者：
Cornelissen, Cynthia Nau
DOI：
10.1038/nrmicro2713
发表时间：
2012-01-31
期刊：
Nature reviews. Microbiology
影响因子：
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作者：
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影响因子：
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作者：
Abergel, Rebecca J.;Clifton, Matthew C.;Pizarro, Juan C.;Warner, Jeffrey A.;Shuh, David K.;Strong, Roland K.;Raymond, Kenneth N.
通讯作者：
Raymond, Kenneth N.
影响因子：
5.1
作者：
Layoun, Antonio;Santos, Manuela M.
通讯作者：
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影响因子：
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作者：
Ducey, TF;Carson, MB;Dyer, DW
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