Proteodermatan sulfate isolated from pig skin.
Proteodermatan sulfate isolated from pig skin.
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从猪皮中分离出硫酸蛋白皮素。
DOI：
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发表时间：
1982
影响因子：
4.8
通讯作者：
John D. Gregory
中科院分区：
文献类型：
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作者：
S. Damle;Lars CosterS;John D. Gregory
猪皮的主要蛋白多糖是一种蛋白皮肤素硫酸盐，在温和的条件下，在蛋白酶抑制剂的存在下被分离出来。经离子交换和凝胶层析纯化后，其相对分子质量为70×10(3)，不与透明质酸形成聚集体。它含有约60%的蛋白质、一条硫酸皮肤素链和几条低聚糖链。硫酸皮肤素含有丰富的艾杜糖酸(占糖醛酸的85%)，不含硫酸软骨素链。低聚糖含有氨基葡萄糖、唾液酸和中性糖。
The major proteoglycan of pig skin, a proteodermatan sulfate, has been isolated under mild conditions in the presence of protease inhibitors. After purification by ion exchange and gel chromatography, it has a Mr of 70 x 10(3) and it does not form aggregates with hyaluronic acid. It contains about 60% protein, one chain of dermatan sulfate, and several oligosaccharide chains. The dermatan sulfate is high in iduronic acid (85% of the uronic acid) and there are no chains of chondroitin sulfate present. The oligosaccharides contain glucosamine, sialic acid, and neutral sugars.