Dysfunction of the sarcoplasmic reticulum in polymyositis.
Dysfunction of the sarcoplasmic reticulum in polymyositis.
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多发性肌炎的肌浆网功能障碍。
DOI：
10.1002/art.1780270309
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发表时间：
1984
影响因子：
--
通讯作者：
Kalovidouris,AE
中科院分区：
文献类型：
--
作者：
Kalovidouris,AE
从6例早期活动性多发性肌炎患者和11例对照患者的肌肉标本中分离出肌浆网小泡钙的转运。同时测量钙摄取的时间过程和钙依赖性atp酶活性。多发性肌炎患者的肌浆网小泡摄钙量比对照组少50% （P< 0.001）。相比之下，在多肌炎患者和对照组的囊泡中，钙依赖性atp酶活性没有差异。所证实的缺陷可能是多肌炎肌无力的重要发病机制。
The transport of calcium in vesicles of sarcoplasmic reticulum isolated from muscle specimens from 6 patients with early, active polymyositis and from 11 controls was examined. The time courses of calcium uptake and calcium‐dependent ATPase activity were measured simultaneously. Calcium uptake by sarcoplasmic reticulum vesicles from patients with polymyositis was 50% less than that by vesicles from controls (P< 0.001). In contrast, no difference in calcium‐dependent ATPase activity was noted between vesicles from patients with polymyositis and controls. The demonstrated defect may be important in the pathogenesis of muscle weakness in polymyositis.