CORTICOSTEROID 11-BETA HYDROXYSTEROID DEHYDROGENASE ACTIVITIES IN VERTEBRATE LIVER
CORTICOSTEROID 11-BETA HYDROXYSTEROID DEHYDROGENASE ACTIVITIES IN VERTEBRATE LIVER
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DOI：
10.1016/0039-128x(88)90118-3
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发表时间：
1988-01-01
期刊：
影响因子：
2.7
通讯作者：
LAKSHMI V
中科院分区：
文献类型：
--
作者：
MONDER C;LAKSHMI V
在这篇文章中，我们研究了脊椎动物肝脏中微粒体11β-羟基类固醇脱氢酶复合体的皮质类固醇11β-氧化和11-还原的性质。在青蛙、青蛙、泥狗、鲨鱼和鸟的肝脏中没有发现氧化方向的肝脏活性(11β-脱氢酶)。相比之下，所有哺乳动物的肝脏都有活性的氧化酶。潜伏期，定义为由洗涤剂Triton DF-18释放的微生物体连接的活动，是所有哺乳动物肝脏中11β-脱氢酶的特性。哺乳动物、鸟类和角鱼的肝脏减少了11-脱氢皮质类固醇(11-还原酶)，而两栖动物和硬骨鱼则没有。除大鼠肝脏外，潜伏期是所有哺乳动物肝脏11-还原酶的特征。
In this paper, we examine corticosteroid 11.beta.-oxidation and 11-reduction as properties of the microsomal 11.beta.-hydroxysteroid dehydrogenase complex in vertebrate livers. No hepatic activity in the oxidative direction (11.beta.-dehydrogenase) was found in the frog, toad, mud puppy, shark, and bird livers. In contrast, all mammalian livers had active oxidizing enzymes. Latency, defined as microsome-linked activity released by the detergent Triton DF-18, was a property of 11.beta.-dehydrogenase in all mammalian livers. Mammal, bird, and dogfish livers reduced 11-dehydrocorticosteroids (11-reductase), while amphibians and bony fish did not. With the exception of rat liver, latency was a property of all the mammalian liver 11-reductases examined.