HPV-associated Oropharyngeal Cancers--Are They Preventable?
HPV-associated Oropharyngeal Cancers--Are They Preventable?
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HPV相关的口咽癌 - 它们是否可以预防？
DOI：
10.1158/1940-6207.capr-11-0379
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发表时间：
2011-09
期刊：
影响因子：
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通讯作者：
Chaturvedi AK
中科院分区：
文献类型：
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作者：
Kreimer AR;Chaturvedi AK
目前尚不清楚人乳头瘤病毒 (HPV) 诱发的口咽癌前病变是否可以通过巴氏试验等效筛查来识别，或者是否存在。在本期杂志（从第 1378 页开始）中，Fakhry 和同事报告了他们的结果，表明口咽的细胞学评估虽然可用于检测侵袭性口咽癌，但作为检测癌前病变的筛查方式可能作用有限。这些发现反对通过筛查和预防癌前病变进展来对 HPV 相关口咽癌进行二级预防的可能性，并强调如果证明有效且具有成本效益，则可以通过预防性 HPV 疫苗接种进行一级预防。
It is not known whether a human papillomavirus (HPV)-induced oropharyngeal precancerous lesion could be identified by screening with a pap test equivalent or whether one even exists. In this issue of the journal (beginning on page 1378), Fakhry and colleagues report their results showing that cytologic evaluation of the oropharynx, although useful in detecting invasive oropharyngeal cancers, may have limited utility as a screening modality for detecting precancer. These findings argue against the potential for secondary prevention of HPV-associated oropharyngeal cancers through screening for and preventing the progression of precancer and highlight the opportunity for primary prevention through prophylactic HPV vaccination, if proven efficacious and cost-effective.