Homochiral α-D- and β-D-isoxazolidinylthymidines via 1,3-dipolar cycloaddition
Homochiral α-D- and β-D-isoxazolidinylthymidines via 1,3-dipolar cycloaddition
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DOI：
10.1021/jo990576a
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发表时间：
1999-12-24
影响因子：
3.6
通讯作者：
Romeo, R
中科院分区：
文献类型：
--
作者：
Chiacchio, U;Corsaro, A;Romeo, R
在起始硝酮的C-或N-原子上引入手性助剂是合成杂环核苷类似物的一条立体选择性合成路线。以氮原子为辅基的碳水化合物的合成效果最好，从而实现了异恶唑烷基胸腺嘧啶26的简单、不对称合成。
The introduction of chiral auxiliaries at the C- or N-atom in starting nitrones has been investigated as a stereoselective synthetic route to heterocyclic nucleoside analogues. The carbohydrate auxiliary at nitrogen atom gave the best results, thus allowing an easy and enantioselective synthesis of isoxazolidinyl thymine 26.