The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari
The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari
复制标题
红芪对二硝基苯磺酸所致溃疡性结肠炎的改善作用
DOI：
10.1111/jfbc.13421
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发表时间：
2020
影响因子：
4
通讯作者：
Lianggong Zhao
中科院分区：
文献类型：
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作者：
Gengen Shi;Donghan Wang;Zhiyuan Xue;Xianglin Zhou;Yaoyao Fang;Shilan Feng;Lianggong Zhao
溃疡性结肠炎（UC）是一种病因不明的慢性炎症性疾病。本研究证明红芪（RH）改善UC。与初步研究一致，通过7天干预，使用4种RH提取物改善2，4-二硝基苯磺酸诱导的UC。与RH提取物治疗相比，RH乙醇提取物（EE）被发现在改善UC方面更有效。EE组DAI明显降低。大体和组织病理学评估表明，结肠粘膜得到修复，结肠组织结构得到重建。MPO、TNF-α、IL-1β和MDA水平显著降低（p< .01），T-SOD和CAT水平显著升高（p< .01）。并采用高效液相色谱法对EE中的化学成分进行了分析。结果表明，EE可以改善UC，其抗炎能力可能起着重要作用。RH可以作为一种功能性食品，改善UC。实际应用在这项工作中，从多个角度评价RH对UC的改善作用。这项工作有两个实际应用。一方面，本工作为改善UC提供了一种新的途径。此外，UC患者有了改善症状的新选择。另一方面，这项工作也提供了如何最好地处理RH用于治疗用途的信息。此外，我们可以利用一些曾经被认为无用的RH化合物，减少自然资源的浪费。
Ulcerative colitis (UC) is a chronic inflammatory disease with an unknown precise etiology. This study proves that Radix Hedysari (RH) ameliorates UC. Four RH extracts were used to ameliorate UC induced by 2,4‐Dinitrobenzenesulfonic acid by 7 days intervention in agreement to preliminary studies. Compared to treatment with RH extracts, the RH ethanol extract (EE) was found to be more effective in ameliorating UC. With EE, the DAI were significantly decreased. Macroscopic and histopathological assessments suggest that the colon mucosa was repaired, the organizational structure of the colon had been rebuilt. The levels of MPO, TNF‐α, IL‐1β, and MDA were significantly decreased (p< .01), the levels of T‐SOD and CAT were significantly increased (p< .01). Moreover, the compounds in EE were analyzed by HPLC. The results show that EE can ameliorate UC, and its anti‐inflammatory capability probably plays an important role. RH can act as a functional food and ameliorate UC.Practical applicationsIn this work, the ameliorative effect of RH on UC was evaluated from multiple angles. There are two practical applications of this work. On the one hand, a new approach to ameliorating UC is provided by this work. In addition, UC patients have a new option for improving their symptoms. On the other hand, this work also provides information on how best to process RH for therapeutic use. In addition, we can utilize some compounds of RH that were once considered useless and reduce the waste of natural resources.