Reduction of intimal hyperplasia in canine autologous vein grafts with cod-liver oil and dipyridamole.
Reduction of intimal hyperplasia in canine autologous vein grafts with cod-liver oil and dipyridamole.
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用鱼肝油和双嘧达莫减少犬自体静脉移植物的内膜增生。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
M. Macauley
中科院分区：
文献类型：
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作者：
R. Landymore;C. Cameron;B. Sheridan;M. Macauley
为了确定鱼肝油和鱼肝油与潘生丁的组合对静脉移植物内膜增生的影响，在38只接受2%胆固醇饮食的杂种狗的双侧股动脉之间插入76段未扩张的颈静脉。10只对照动物仅接受饮食，8只在手术前1周和手术后6周每天接受含有1.8 g二十碳五烯酸的鱼肝油，20只狗在手术前1周和手术后6周每天接受1.8 g二十碳五烯酸和75 mg双嘧达莫。在所有三组中均观察到血清胆固醇相似且显著（p <0.01）升高。凝血酶原、部分凝血活酶和凝血时间以及血小板计数在对照组和接受鱼肝油的患者中没有变化。接受鱼肝油和双嘧达莫组合的动物的凝血时间增加（p小于0.001）。对每个移植物进行内膜厚度测量（406 +/- 27）。对照组植入前内膜厚度为3.7 +/- 0.1微米，植入后增加至78 +/- 8微米。鱼肝油将内膜增厚的增加限制在24 +/- 3微米（p <0.001）;鱼肝油和潘生丁进一步将内膜增厚的增加减少到17 +/- 1.4微米（p <0.001）。数据表明，鱼肝油和双嘧达莫的组合在减少犬静脉移植物内膜增生方面比鱼肝油单独使用更有效（p <0.03）。
To determine the effects of cod-liver oil and a combination of cod-liver oil and dipyridamole on vein-graft intimal hyperplasia, 76 segments of undistended jugular vein were interposed between bilaterally divided femoral arteries in 38 mongrel dogs who received a 2% cholesterol diet. Ten control animals received the diet alone, 8 received cod-liver oil containing 1.8 g of eicosapentaenoic acid daily 1 week before and for 6 weeks after operation, and 20 dogs received 1.8 g of eicosapentaenoic acid and 75 mg of dipyridamole daily 1 week before and for 6 weeks after operation. A similar and significant (p less than 0.01) increase in serum cholesterol was observed in all three groups. Prothrombin, partial thromboplastin and clotting times and the platelet count were unchanged in the controls and in those receiving cod-liver oil. Clotting time increased in the animals receiving a combination of cod-liver oil and dipyridamole (p less than 0.001). Measurements (406 +/- 27) of intimal thickness were made from each graft. Intimal thickness was 3.7 +/- 0.1 micron before implantation and increased to 78 +/- 8 micron after in the controls. Cod-liver oil limited the increase in intimal thickening, to 24 +/- 3 micron (p less than 0.001); cod-liver oil and dipyridamole further reduced the increase in intimal thickening, to 17 +/- 1.4 micron (p less than 0.001). The data indicate that a combination of cod-liver oil and dipyridamole is more effective than cod-liver oil alone in reducing canine vein-graft intimal hyperplasia (p less than 0.03).