Zymocin, a composite chitinase and tRNase killer toxin from yeast
Zymocin, a composite chitinase and tRNase killer toxin from yeast
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DOI：
10.1042/bst0351533
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发表时间：
2007-12-01
影响因子：
3.9
通讯作者：
Schaffrath, R.
中科院分区：
文献类型：
--
作者：
Jablonowski, D.;Schaffrath, R.
乳酸克鲁维酵母（Kluyveromyceslactis）中的质粒编码的三甲基（α β γ）发酵菌素毒素对酿酒酵母的生长抑制依赖于芽殖酵母中的多步反应途径。在通过发酵蛋白的几丁质酶a亚基介导细胞表面接触的早期过程之后，后期步骤使得能够输入γ毒素tRNase亚基并切割携带修饰的U34（摆动尿苷）碱基的靶tRNA。随着类似zympocin的毒素的出现，对zymocin的持续研究有望对酵母病理系统的演变及其致命作用模式产生新的见解。
Growth inhibition of Soccharomyces cerevisicie by the plasmid-encocled trimefic (alpha beta gamma) zymocin toxin from dairy yeast, Kluyveromyces lactis, depends on a multistep response pathway in budding yeast. Following early processes that mediate cell-surface contact by the chitinase a-subunit of zymocin, later steps enable import of the gamma-toxin tRNase subunit and cleavage of target tRNAs that carry modified U34 (wobble uridine) bases. with the emergence of zympocin-like toxins, continued zymocin research is expected to yield new insights into the evolution of yeast pathosystems and their lethal modes of action.