Regenerative abilities of mesenchymal stem cells through mitochondrial transfer.
Regenerative abilities of mesenchymal stem cells through mitochondrial transfer.
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DOI：
10.1186/s12929-018-0429-1
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发表时间：
2018-03-30
影响因子：
11
通讯作者：
Mohanty S
中科院分区：
文献类型：
--
作者：
Paliwal S;Chaudhuri R;Agrawal A;Mohanty S
在过去的十年里，研究表明线粒体转移是一种新兴的机制，通过它间充质干细胞（MSC）可以再生和修复受损的细胞或组织。已发现它在治疗与脑损伤、心肌病、肌肉败血症、肺部疾病和急性呼吸系统疾病有关的几种疾病中发挥关键作用。一些研究表明，线粒体转移涉及多种机制，包括隧道管形成、微囊泡形成、间隙连接、细胞融合和其他转移模式。很少有研究调查了有助于线粒体转移的机制，主要包括参与隧道管形成的信号通路，其促进隧道管形成以使线粒体从一个细胞移动到另一个细胞。各种应激信号，如受损线粒体、mtDNA和线粒体产物的释放沿着活性氧水平升高，触发线粒体从MSC转移到受体细胞。然而，导致线粒体从健康细胞转移的广泛的细胞信号传导途径仍在研究中，并且有助于受体细胞中线粒体生物能量学恢复的变化在很大程度上仍然难以捉摸。在这篇综述中，我们讨论了线粒体从MSC转移到邻近的应激细胞的现象，以及这如何有助于不同器官（如肺，心脏，眼睛，大脑和肾脏）的细胞修复和再生。线粒体转移的潜在范围提供了新的治疗策略，用于治疗各种病理生理条件也进行了讨论。
The past decade has witnessed an upsurge in studies demonstrating mitochondrial transfer as one of the emerging mechanisms through which mesenchymal stem cells (MSCs) can regenerate and repair damaged cells or tissues. It has been found to play a critical role in healing several diseases related to brain injury, cardiac myopathies, muscle sepsis, lung disorders and acute respiratory disorders. Several studies have shown that various mechanisms are involved in mitochondrial transfer that includes tunnel tube formation, micro vesicle formation, gap junctions, cell fusion and others modes of transfer. Few studies have investigated the mechanisms that contribute to mitochondrial transfer, primarily comprising of signaling pathways involved in tunnel tube formation that facilitates tunnel tube formation for movement of mitochondria from one cell to another. Various stress signals such as release of damaged mitochondria, mtDNA and mitochondrial products along with elevated reactive oxygen species levels trigger the transfer of mitochondria from MSCs to recipient cells. However, extensive cell signaling pathways that lead to mitochondrial transfer from healthy cells are still under investigation and the changes that contribute to restoration of mitochondrial bioenergetics in recipient cells remain largely elusive. In this review, we have discussed the phenomenon of mitochondrial transfer from MSCs to neighboring stressed cells, and how this aids in cellular repair and regeneration of different organs such as lung, heart, eye, brain and kidney. The potential scope of mitochondrial transfer in providing novel therapeutic strategies for treatment of various pathophysiological conditions has also been discussed.
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影响因子：
3.7
作者：
Takahashi A;Hirohashi Y;Torigoe T;Tamura Y;Tsukahara T;Kanaseki T;Kochin V;Saijo H;Kubo T;Nakatsugawa M;Asanuma H;Hasegawa T;Kondo T;Sato N
通讯作者：
Sato N
影响因子：
7.7
作者：
Dong, Lan-Feng;Kovarova, Jaromira;Neuzil, Jiri
通讯作者：
Neuzil, Jiri
影响因子：
3.3
作者：
Huang, Po-Jui;Kuo, Chi-Chung;Su, Hong-Lin
通讯作者：
Su, Hong-Lin
间充质干细胞的线粒体转移有效保护角膜上皮细胞免受线粒体损伤。
影响因子：
9
作者：
Jiang D;Gao F;Zhang Y;Wong DS;Li Q;Tse HF;Xu G;Yu Z;Lian Q
通讯作者：
Lian Q
影响因子：
37.8
作者：
Barbash, IM;Chouraqui, P;Leor, J
通讯作者：
Leor, J