Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes
Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes
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DOI：
10.2337/dc06-2426
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发表时间：
2007-03
期刊：
影响因子：
16.2
通讯作者：
Y. Cho;Byung-Soo Youn;K. Park
中科院分区：
文献类型：
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作者：
Y. Cho;Byung-Soo Youn;K. Park
目的脂肪因子的失调与胰岛素抵抗和2型糖尿病的发病密切相关。视黄醇结合蛋白-4 （RBP4）是一种新的脂肪因子，最近被报道在肥胖和胰岛素抵抗之间提供了联系。在这里，我们研究了人类血浆RBP4浓度与各种代谢参数之间的关系。研究设计和方法采用酶联免疫吸附法测定人RBP4血浆浓度，并将其与糖耐量正常（NGT, n = 57）、糖耐量受损（IGT, n = 48）和2型糖尿病（n = 49）受试者的胰岛素抵抗相关参数进行比较。结果IGT组和2型糖尿病组血浆RBP4浓度高于NGT组（中位值分别为18.9[范围11.2-45.8]、20.9[范围9.9-48.5]和18.1微克/毫升[9.3-30.5]）。然而，IGT组和2型糖尿病组的血浆RBP4浓度没有差异。血浆RBP4浓度与性别、腰围、空腹血糖和胰岛素抵抗有关。其中，性别和空腹血糖水平被发现是血浆RBP4浓度的独立决定因素。结论：血浆RBP4浓度在IGT或2型糖尿病患者中升高，并与已知与胰岛素抵抗相关的各种临床参数有关。
OBJECTIVE The dysregulation of adipokines is closely associated with the pathogenesis of insulin resistance and type 2 diabetes. Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance. Here, we examined the relation between plasma RBP4 concentrations and various metabolic parameters in humans. RESEARCH DESIGN AND METHODS An enzyme-linked immunosorbent assay was developed to measure human RBP4 plasma concentrations, which were then compared with various parameters related to insulin resistance in subjects with normal glucose tolerance (NGT; n = 57), impaired glucose tolerance (IGT; n = 48), and type 2 diabetes (n = 49). RESULTS Plasma RBP4 concentrations were higher in the IGT and type 2 diabetic groups than in the NGT group (median 18.9 [range 11.2-45.8], 20.9 [9.9-48.5], and 18.1 microg/ml [9.3-30.5], respectively). However, no difference was found between plasma RBP4 concentrations in the IGT and type 2 diabetic groups. Plasma RBP4 concentrations were found to be associated with sex, waist circumference, fasting plasma glucose, and insulin resistance. Of these, sex and fasting plasma glucose levels were found to be independent determinants of plasma RBP4 concentration. CONCLUSIONS Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance.