Digital Biomarker Applications Across the Spectrum of Opioid Use Disorder.
Digital Biomarker Applications Across the Spectrum of Opioid Use Disorder.
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DOI：
10.1080/28324765.2023.2240375
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发表时间：
2023-08
期刊：
影响因子：
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通讯作者：
M. Rigatti;Brittany P. Chapman;P. Chai;D. Smelson;K. Babu;Stephanie P Carreiro
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文献类型：
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作者：
M. Rigatti;Brittany P. Chapman;P. Chai;D. Smelson;K. Babu;Stephanie P Carreiro
阿片类药物使用障碍（OUD）是过去十年中最紧迫的公共卫生问题之一，仅在2021年就有超过8万例与过量使用相关的死亡。用于测量和应对疾病状态的数字技术包括体内和体外传感器。此类设备可用于检测和监测与关注事件、健康或病理相关的终端用户生理或行为测量值（即数字生物标志物）。近期的研究已经证明了数字生物标志物作为预防、降低风险以及治疗阿片类药物使用障碍的工具的潜力。在使用阿片类药物的过程中会发生多种生理适应性变化，这代表了基于数字生物标志物监测策略的潜在目标。本综述探讨了在阿片类药物使用的各个阶段进行数字生物标志物监测的现有证据（及潜力）。将对检测阿片类药物使用、戒断、痛觉过敏和过量的技术进行综述。在基于经验得出的算法驱动下，这些技术对于支持阿片类药物的安全处方、减少阿片类药物使用者的伤害以及支持阿片类药物使用障碍康复者具有重要意义。
Opioid use disorder (OUD) is one of the most pressing public health problems of the past decade, with over eighty thousand overdose related deaths in 2021 alone. Digital technologies to measure and respond to disease states encompass both on- and off-body sensors. Such devices can be used to detect and monitor end-user physiologic or behavioral measurements (i.e. digital biomarkers) that correlate with events of interest, health, or pathology. Recent work has demonstrated the potential of digital biomarkers to be used as a tools in the prevention, risk mitigation, and treatment of opioid use disorder (OUD). Multiple physiologic adaptations occur over the course of opioid use, and represent potential targets for digital biomarker based monitoring strategies. This review explores the current evidence (and potential) for digital biomarkers monitoring across the spectrum of opioid use. Technologies to detect opioid administration, withdrawal, hyperalgesia and overdose will be reviewed. Driven by empirically derived algorithms, these technologies have important implications for supporting the safe prescribing of opioids, reducing harm in active opioid users, and supporting those in recovery from OUD.