Clustering of 770,000 genomes reveals post-colonial population structure of North America.
Clustering of 770,000 genomes reveals post-colonial population structure of North America.
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DOI：
10.1038/ncomms14238
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发表时间：
2017-02-07
影响因子：
16.6
通讯作者：
Ball CA
中科院分区：
文献类型：
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作者：
Han E;Carbonetto P;Curtis RE;Wang Y;Granka JM;Byrnes J;Noto K;Kermany AR;Myres NM;Barber MJ;Rand KA;Song S;Roman T;Battat E;Elyashiv E;Guturu H;Hong EL;Chahine KG;Ball CA
尽管在从遗传多态性数据表征人类历史方面取得了进展，但在识别近期人口统计学的遗传特征方面的进展有限。在这里，我们从77万个美国血统的基因型个体中超过5亿个遗传（血统认同，IBD）连接的网络中确定了北美最近的精细规模人口结构。我们检测网络中密集连接的聚类，并使用超过2000万个家谱记录的数据库来注释这些聚类。IBD集群捕捉到的最近人口模式包括斯堪的纳维亚人和法裔加拿大人等移民;波多黎各人等大陆混血群体;阿米什人和阿巴拉契亚人等经历过地理或文化孤立的定居者;以及广泛的历史趋势，包括减少南北基因流动。我们的研究结果产生了一个详细的历史画像北美欧洲定居后，并支持大量的遗传异质性在美国超出了以前的研究发现。遗传数据使我们对人类进化和扩散的理解取得了巨大进展，但有关最近事件的信息有限。在这里，作者分析了77万美国人的基因型，以绘制欧洲人定居后北美的精细人口结构。
Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies. Genetic data has led to great advances in our understanding of human evolution and dispersal, but information on more recent events is limited. Here, the authors analyse genotypes from 770,000 US individuals to map the fine-scale population structure of North America after European settlement.