PORTABLE SYSTEM FOR QUANTIFYING MOTOR ABNORMALITIES IN PARKINSONS-DISEASE
PORTABLE SYSTEM FOR QUANTIFYING MOTOR ABNORMALITIES IN PARKINSONS-DISEASE
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DOI：
10.1109/10.216411
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发表时间：
1993-03-01
影响因子：
4.6
通讯作者：
GROWDON, JH
中科院分区：
文献类型：
--
作者：
GHIKA, J;WIEGNER, AW;GROWDON, JH
为了量化帕金森氏病（PD）的运动障碍，我们设计了一个紧凑的，便携式的，基于个人电脑的神经生理系统来测量震颤，运动迟缓，和肌肉张力。震颤由固态加速度计检测并转化为数字信号。该系统显示均方根位移和频率分布的震颤在水平和垂直平面，沿着重建的图形图像的位移。运动迟缓是使用一个面板来测量的，该面板检测响应听觉和视觉信号的开关的释放和按压;该系统以毫秒为单位计算受试者的反应时间和运动时间。通过将上肢绑在轻质低摩擦摇篮上，然后用仪器手柄被动移动摇篮来测量手肘的张力。代表扭矩和臂角度的信号由计算机处理，并在屏幕上以真实的时间显示，刚度作为平均斜率，单位为Nm/度。在临床试验中，与对照组相比，PD患者的震颤、运动时间和僵硬度的定量测量值显著异常。我们的结论是，该系统是一个方便和准确的方法来量化的帕金森综合征的重要方面，并可应用于量化其他运动障碍。
In order to quantify motor disabilities in Parkinson's disease (PD), we designed a compact, portable, neurophysiological system based upon a personal computer to measure tremor, bradykinesia, and muscle tone. Tremor was detected by solid state accelerometers and translated into a digital signal. The system displayed the root mean square displacements and frequency distribution of the tremor in the horizontal and vertical planes, along with a reconstructed graphic image of the displacement. Bradykinesia was measured using a panel that detects release and depression of switches in response to auditory and visual signals; the system calculated subjects' reaction times and movement times in milliseconds. Tone at the elbow was measured by strapping the upper extremity to a lightweight low-friction cradle and then passively moving the cradle with an instrumented handle. Signals representing torque and arm angle were processed by the computer and displayed in real time on the screen with stiffness as a mean slope in Nm/degree. In clinical tests, quantitative measures of tremor, movement time and rigidity were significantly abnormal in PD patients compared to control subjects. We conclude that this system is a convenient and accurate method to quantitate important aspects of the parkinsonian syndrome, and may be applied to quantitate other movement disorders.