Naturally occurring anti-band 3 autoantibodies recognize a high molecular weight protein on the surface of Plasmodium falciparum infected erythrocytes.
Naturally occurring anti-band 3 autoantibodies recognize a high molecular weight protein on the surface of Plasmodium falciparum infected erythrocytes.
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天然存在的抗带 3 自身抗体可识别恶性疟原虫感染的红细胞表面的高分子量蛋白质。
DOI：
10.1016/s0006-291x(89)80153-6
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发表时间：
1989
影响因子：
3.1
通讯作者：
Sherman,IW
中科院分区：
文献类型：
--
作者：
Winograd,E;Sherman,IW
天然存在的抗带3自身抗体与感染人恶性疟原虫（FCR-3株）的多节变异体的红细胞结合。自身抗体识别由表面碘化感染的红细胞制备的SDS提取物中的> 240 kDa蛋白。该抗原仅与感染多节变体的红细胞相关，并通过胰蛋白酶处理完整的感染细胞而被去除。通过二维肽图分析，该抗原被证明在结构上与人红细胞阴离子转运蛋白带3相关。
Naturally occurring anti-band 3 autoantibodies bind to erythrocytes infected with a knobby variant of the human malariaPlasmodiumfalciparum(FCR-3 strain). The autoantibodies recognized a > 240 kDa protein in SDS extracts made from surface iodinated infected erythrocytes. The antigen was associated only with erythrocytes infected with a knobby variant, and was removed by trypsin treatment of intact infected cells. By two-dimensional peptide map analysis the antigen was shown to be structurally related to the human erythrocyte anion transporter, band 3.