Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice.
Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice.
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DOI：
10.1034/j.1600-0544.2002.02225.x
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发表时间：
2002-11-01
影响因子：
3.1
通讯作者：
Peterkova, R
中科院分区：
文献类型：
--
作者：
Kristenova, P;Peterka, M;Peterkova, R
目的：对出生后高度变异的虎斑（Ta）小鼠下磨牙牙列进行分类。Ta综合征与人类无汗性（少汗性）外胚层发育不良（EDA）同源，包括牙齿、毛发和汗腺的严重发育缺陷。设计：分析牙齿形状和牙尖模式，测量近远中牙冠长度。1995- 2001年收集了107只出生后11天至成年的纯合子和半合子虎斑（Ta）小鼠及90只野生型小鼠的头部固定标本。减少牙齿长度在Ta牙齿和牙齿长度之间的具体差异不同morphotypes.Results：变量牙列在Ta小鼠的下磨牙区被归类为两个基本的形态类型I和II。形态型I进一步细分为特定的形态型Ia、Ib和Ic。基本形态型I和II的比例是不同的杂合子（84%和12%）与纯合子+半合子（45%和52%）的母亲的后代。在一个基本的morphotype. CONCLUSION特定的形态类型的比例是相似的后代groups.CONCLUSION：不同的形态类型的识别有可能分类的结构变异性的下颌功能性牙列在Ta小鼠。
OBJECTIVES: To sort and classify the highly variable lower molar dentition in tabby (Ta) mice postnatally. The Ta syndome is homologous to the anhidrotic (hypohidrotic) ectodermal dysplasia (EDA) in human and includes severe developmental defects of teeth, hair and sweat glands.DESIGN: Analysis of tooth shape and cusp pattern and measurement of the mesio-distal crown length.SETTING AND SAMPLE POPULATION: Institute of Experimental Medicine, Academy of Sciences, Prague. Fixed heads of 107 tabby (Ta) homozygous and hemizygous mice and 90 wild type mice aged from post-natal day 11 to adulthood, collected during 1995-2001.OUTCOME MEASURE: Identification of distinct morphotypes of Ta dentition. Reduced tooth length in Ta teeth and specific differences in tooth length between distinct morphotypes.RESULTS: The variable dentitions in the lower molar region of Ta mice were classified in two basic morphotypes I and II. The morphotype I was further subdivided into particular morphotypes Ia, Ib and Ic. Proportion of the basic morphotypes I and II was different in the offspring of heterozygous (84% and 12%) compared with homozygous + hemizygous (45% and 52%) mothers. The proportions of particular morphotypes within a basic morphotype were similar in both offspring groups.CONCLUSION: The identification of the distinct morphotypes made possible to classify the structural variability of the mandibular functional dentition in Ta mice.