Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: A Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations.
Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: A Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations.
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DOI：
10.1097/md.0000000000001901
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发表时间：
2015-10
期刊：
影响因子：
1.6
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Zhu QQ;Zhang XL;Zhang SM;Tang SW;Min HY;Yi L;Xu B;Song Y
特发性肺纤维化（IPF）是一种预后不良的进行性疾病。许多研究报道了MUC5B启动子多态性rs35705950与IPF之间的关联，但观察到大量不一致的结果，关联强度尚不清楚。本研究的目的是调查不同民族人群中rs35705950与IPF之间的关系。检索了PubMed、EMBASE、Web of Science和CENTRAL从成立到2015年4月15日的数据库。等位基因和表型的比较是分开进行的，高加索和亚洲人群的比较也是分开进行的。采用试验序贯分析进行meta分析。纳入了7篇全文文章中的9项研究，包括2733名IPF患者和5044名对照。6项研究在高加索人群中进行，3项在亚洲人群中进行。与G等位基因相比，较小的T等位基因与IPF风险增加相关（优势比[OR] 4.85, 95%可信区间[CI] 3.79-6.21, P = 5.88 × 10−36），TG和TT基因型与GG基因型相关（TG vs GG: OR 6.20, 95% CI 5.14-7.48, P = 1.70 × 10−81;TT vs GG: OR 11.29, 95% CI 5.69-22.40, P = 4.22 × 10−12），呈等位基因剂量依赖性。这些观察结果在两个人群的试验序列分析中得到证实。与亚洲人群相比，白种人人群的关联强度更显著，本研究未在亚洲人群中检测到纯合子TT基因型。我们的研究显示MUC5B启动子rs35705950多态性与IPF风险之间存在很强的相关性。rs35705950小T等位基因与IPF易感性之间的关联强度在高加索人群中尤为明显，在亚洲人群中较弱但仍然显著。
Supplemental Digital Content is available in the text Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. A number of studies reported the association between MUC5B promoter polymorphism rs35705950 and IPF, but substantial inconsistent findings were observed and the strength of association remains unclear. The aim of the study was to investigate the association between rs35705950 and IPF in different ethnic populations. PubMed, EMBASE, Web of Science, and CENTRAL were searched from their inception to April 15, 2015. Allelic and phenotypic comparisons were conducted separately, as were comparisons in Caucasian and Asian populations. A meta-analysis with trial sequential analysis was conducted. Nine studies presented in 7 full-text articles were included, encompassing 2733 IPF patients and 5044 controls. Six studies were carried out in the Caucasian population, and 3 in the Asian population. Minor T allele was associated with an increased risk of IPF compared with G allele (odds ratio [OR] 4.85, 95% confidence interval [CI] 3.79–6.21, P = 5.88 × 10−36), as were TG and TT genotypes compared with GG genotype (TG vs GG: OR 6.20, 95% CI 5.14–7.48, P = 1.70 × 10−81; TT vs GG: OR 11.29, 95% CI 5.69–22.40, P = 4.22 × 10−12), in an allele dose-dependent manner. These observations were confirmed in trial sequential analysis in both populations. The strength of association was more remarkable in the Caucasian population than in the Asian population, and no homozygous TT genotype was detected in the Asian population in our study. Our study revealed strong association between the MUC5B promoter rs35705950 polymorphism and the risk of IPF. The strength of association between rs35705950 minor T allele and IPF susceptibility was particularly evident in the Caucasian population, and milder but still significant in the Asian population.