Stem cells and their niches: integrated units that maintain Drosophila tissues.
Stem cells and their niches: integrated units that maintain Drosophila tissues.
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DOI：
10.1101/sqb.2008.73.023
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
A. Spradling;Todd G. Nystul;D. Lighthouse;L. Morris;Donald T. Fox;Rachel T. Cox;Tina L. Tootle;R. Frederick;Andrew D. Skora
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文献类型：
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作者：
A. Spradling;Todd G. Nystul;D. Lighthouse;L. Morris;Donald T. Fox;Rachel T. Cox;Tina L. Tootle;R. Frederick;Andrew D. Skora
对四种不同的果蝇干细胞及其小生境的遗传分析揭示了可能广泛应用的干细胞生物学原理。干细胞和它的小生境一起作为一个系统的组成部分，在组织内需要的时候和地方提供替代细胞。干细胞/生态位单位受到高度管制，尽管其所有组成细胞定期更替和更换，但仍继续运作。为了成功应对组织需求，这些单位接收和处理广泛的本地和系统信息。干细胞单独在这项任务中并不比一个孤立的神经元更有用。只有当干细胞整合到多个相互作用的细胞系统（小生境）中时，干细胞才能成为组织稳态和修复的基本单位。
The genetic analysis of four distinct Drosophila stem cells and their niches has revealed principles of stem cell biology that are likely to apply widely. A stem cell and its niche act together as integral parts of a system that supplies replacement cells when and where they are needed within a tissue. Stem cell/niche units are highly regulated and continue to operate despite the periodic turnover and replacement of all of their component cells. To successfully respond to tissue needs, these units receive and process a wide range of local and systemic information. A stem cell alone would be no more use at this task than an isolated neuron. It is only when integrated into a system of multiple interacting cells (the niche) that stem cells achieve the capacity to serve as the fundamental units of tissue homeostasis and repair.