Lifetime exercise activity and breast cancer risk among post-menopausal women
Lifetime exercise activity and breast cancer risk among post-menopausal women
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DOI：
10.1038/sj.bjc.6690610
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发表时间：
1999-08-01
影响因子：
8.8
通讯作者：
Bernstein, L
中科院分区：
文献类型：
--
作者：
Carpenter, CL;Ross, RK;Bernstein, L
在年轻女性中，终身锻炼与乳腺癌风险有关。然而，还没有研究专门评估终生锻炼活动是否与绝经后女性患乳腺癌的风险有关。我们对居住在美国加利福尼亚州洛杉矶县的55-绝经后白人妇女(1 123例新诊断病例和904例健康对照)进行了一项基于人群的病例对照研究，以评估这种关系。虽然从月经初潮到40岁的锻炼活动和40岁以后的锻炼都不能单独预测乳腺癌的风险，但自月经初潮以来每周锻炼至少17.6个小时(代谢相当于能量消耗乘以活动小时)的女性患乳腺癌的风险低于不锻炼的女性(优势比(OR)=0.55：95%可信区间(CI)0.37-0.83)。对于成年后体重增加相当(17%)的女性来说，运动锻炼并不具有保护作用；然而，在体重较为稳定的女性中，那些在一生中坚持高水平锻炼的人(OR=0.42；95%CI 0.24-0.75)，那些每周锻炼超过4小时至少12年的人(OR=0.59；95%GI 0.40-0.88)，以及那些在最近10年里剧烈锻炼(每周24.5个小时)的人(OR=0.52；95%可信区间为0.32~0.85)。剧烈运动似乎可以降低绝经后女性患乳腺癌的风险，这些女性成年后体重不会增加很多。
Lifetime exercise activity has been linked to breast cancer risk among young women. However, no study has specifically evaluated whether lifetime exercise activity is related to the breast cancer risk of post-menopausal women. We conducted a population-based case-control study of post-menopausal white women (1123 newly diagnosed cases and 904 healthy controls) aged 55-64 who lived in Los Angeles County California, USA to evaluate this relationship. Although neither exercise activity from menarche to age 40 years, nor exercise after age 40 separately predicted breast cancer risk, risk was lower among women who had exercised each week for at least 17.6 MET-hours (metabolic equivalent of energy expenditure multiplied by hours of activity) since menarche than among inactive women (odds ratio (OR) = 0.55: 95% confidence interval (CI) 0.37-0.83). Exercise activity was not protective for women who gained considerable (>17%) weight during adulthood; However, among women with more stable weight, breast cancer risk was substantially reduced for those who consistently exercised at high levels throughout their lifetime (OR = 0.42; 95% CI 0.24-0.75), those who exercised more than 4 h per week for at least 12 years (OR = 0.59; 95% GI 0.40-0.88), and those who exercised Vigorously (24.5 MET-hours per week) during the most recent 10 years (OR = 0.52; 95% CI 0.32-0.85). Strenuous exercise appears to reduce breast cancer risk among post-menopausal women who do not gain sizable amounts of weight during adulthood.