Anatomic and functional topography of the dorsal raphe nucleus
Anatomic and functional topography of the dorsal raphe nucleus
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DOI：
10.1196/annals.1296.005
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Lowry, CA
中科院分区：
文献类型：
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作者：
Abrams, JK;Johnson, PL;Lowry, CA
5-羟色胺能系统在睡眠-觉醒状态和行为唤醒的调节中起着重要和广泛的作用。最近在动物体内的电生理记录研究表明，脑干中缝核内存在几种不同亚型的多巴胺能神经元与独特的行为相关性，提高的可能性，拓扑组织的多巴胺能神经元亚群可能具有独特的行为或生理相关性和独特的功能特性。我们已经表明，压力相关的和焦虑的神经肽促肾上腺皮质激素释放因子可以刺激在中缝背核（DR）内的拓扑结构组织的肾上腺皮质能神经元亚群的体外神经元放电率。这些发现与大量的行为研究一致，表明DR内的多巴胺能系统参与了持续焦虑相关行为的调节和行为敏化，这是一个焦虑和恐惧相关行为反应敏化长达24至48小时的过程。DR的背内侧细分，特别是其中间和尾部方面，已经引起了相当大的关注，作为一个区域，可能在急性和慢性焦虑状态的调节中发挥关键作用。未来的研究，旨在表征的拓扑结构组织亚群的多巴胺能神经元的分子和细胞特性可能会导致我们的理解的压力相关的生理和行为的多巴胺能系统的作用的重大进展。
Serotonergic systems play an important and generalized role in regulation of sleep-wake states and behavioral arousal. Recent in vivo electro-physiologic recording studies in animals suggest that several different subtypes of serotonergic neurons with unique behavioral correlates exist within the brainstem raphe nuclei, raising the possibility that topographically organized subpopulations of serotonergic neurons may have unique behavioral or physiologic correlates and unique functional properties. We have shown that the stress-related and anxiogenic neuropeptide corticotropin-releasing factor can stimulate the in vitro neuronal firing rates of topographically organized subpopulations of serotonergic neurons within the dorsal raphe nucleus (DR). These findings are consistent with a wealth of behavioral studies suggesting that serotonergic systems within the DR are involved in the modulation of ongoing anxiety-related behavior and in behavioral sensitization, a process whereby anxiety- and fear-related behavioral responses are sensitized for a period of up to 24 to 48 h. The dorsomedial subdivision of the DR, particularly its middle and caudal aspects, has attracted considerable attention as a region that may play a critical role in the regulation of acute and chronic anxiety states. Future studies aimed at characterization of the molecular and cellular properties of topographically organized subpopulations of serotonergic neurons are likely to lead to major advances in our understanding of the role of serotonergic systems in stress-related physiology and behavior.