Clostridioides difficile and the Microbiota Early in Life.
Clostridioides difficile and the Microbiota Early in Life.
复制标题
艰难梭菌和生命早期的微生物群。
DOI：
10.1093/jpids/piab063
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发表时间：
2021
影响因子：
3.2
通讯作者：
Zackular,JosephP
中科院分区：
文献类型：
--
作者：
Semon,AlexaK;Keenan,Orlaith;Zackular,JosephP
艰难梭菌是一种孢子形成的专性厌氧菌，普遍存在于医院的病原体。WhileC。成人感染艰难梭菌可引起一系列疾病，包括假膜性结肠炎和中毒性巨结肠，健康婴儿无症状定植率高。导致高定植率的机制和对婴儿的保护。困难目前未知；然而，肠道微生物群的生态和代谢状态是已知的影响ec的因素。difficilepathogenesis。在这篇综述中，我们将研究可能导致c发病率的早期微生物组的各个方面。婴儿疾病表现的困难和保护。我们还将讨论成人微生物群的特征是否能够和限制c。困难菌在生命早期的殖民时期很普遍。
Clostridioides difficileis a spore-forming, obligate anaerobe, and ubiquitous nosocomial pathogen. WhileC. difficileinfection in adults causes a spectrum of disease, including pseudomembranous colitis and toxic megacolon, healthy infants are asymptomatically colonized at high rates. The mechanisms leading to high colonization rates and infant protection fromC. difficileare currently unknown; however, the ecology and metabolic state of the intestinal microbiome are factors known to influenceC. difficilepathogenesis. In this review, we will examine the aspects of the early-life microbiome that may contribute to the incidence ofC. difficileand protection from disease manifestation in infants. We will also discuss whether features of the adult microbiota that enable and restrictC. difficileare prevalent during early-life colonization.