Microfracture and Augments
Microfracture and Augments
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DOI：
10.1055/s-0031-1299654
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发表时间：
2012-03-01
影响因子：
1.7
通讯作者：
Gomoll, Andreas H.
中科院分区：
文献类型：
--
作者：
Gomoll, Andreas H.
微骨折在临床上广泛用于治疗有症状的软骨缺陷。虽然在严格适应症下用于治疗股骨髁中较小的缺损时有效，但当用于较大的或髌股缺损时，所得的纤维软骨修复组织随着时间的推移而显示出退化。本文回顾了标准微骨折的适应症、技术和结果。它还概述了生物材料和生长因子等增强装置，这些装置有可能增强微骨折的效果，并可能扩大其适应症以包括较大的缺陷和其他位置。讨论的增强技术包括胶原蛋白和聚合物膜、壳聚糖和纤维蛋白凝胶、透明质酸注射以及多种生长因子。
Microfracture is in widespread clinical use as an intervention for symptomatic cartilage defects. While effective when used with strict indications for the treatment of smaller defects in the femoral condyles, the resultant fibrocartilaginous repair tissue has shown degradation over time when used in larger or patellofemoral defects. This article reviews the indications, technique, and results of standard microfracture. It also provides an overview of augmentation devices such as biomaterials and growth factors that have the potential to enhance the outcomes of microfracture, potentially widening its indications to include larger defects and other locations. Augmentation techniques discussed include collagen and polymer membranes, chitosan and fibrin gels, hyaluronan injections, as well as numerous growth factors.