The formation and function of ER-endosome membrane contact sites.
The formation and function of ER-endosome membrane contact sites.
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DOI：
10.1016/j.bbalip.2016.01.020
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Eden ER
中科院分区：
文献类型：
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作者：
Eden ER
膜接触位点（MCS）生物学的最新进展揭示了MCS在细胞器间交换中的关键作用，其重要性正变得越来越明显。已报道MCSs在许多重要生理过程中的作用，包括脂质转移、钙交换、受体酪氨酸激酶信号传导、脂滴形成、自噬体形成、细胞器动力学和神经突生长。内质网形成了一个广泛的和动态的网络MCS与各种功能不同的细胞器。ER和内吞途径之间的MCS特别丰富，表明重要的生理作用。在这里，我们目前的知识ER接触网站的形成和功能的内吞细胞器的研究在哺乳动物系统进行了审查。它们的相对不明确的分子组成和最近确定的功能进行了讨论。此外，可能的，但尚未建立，这些接触在脂质转移和钙信号的作用被认为是。这篇文章是由Tim P. Levine和Anant K.梅农ER蛋白VAPA在膜接触位点（MCS）与内体蛋白相互作用。MCS在内体分裂、定位和生长因子受体调节中起作用。ER-内体MCS在脂质转运和Ca 2+信号传导中的作用
Recent advances in membrane contact site (MCS) biology have revealed key roles for MCSs in inter-organellar exchange, the importance of which is becoming increasingly apparent. Roles for MCSs in many essential physiological processes including lipid transfer, calcium exchange, receptor tyrosine kinase signalling, lipid droplet formation, autophagosome formation, organelle dynamics and neurite outgrowth have been reported. The ER forms an extensive and dynamic network of MCSs with a diverse range of functionally distinct organelles. MCSs between the ER and endocytic pathway are particularly abundant, suggesting important physiological roles. Here, our current knowledge of the formation and function of ER contact sites with endocytic organelles from studies in mammalian systems is reviewed. Their relatively poorly defined molecular composition and recently identified functions are discussed. In addition, likely, but yet to be established, roles for these contacts in lipid transfer and calcium signalling are considered. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. ER protein VAPA interacts with endosomal proteins at membrane contact sites (MCS). MCS function in endosome fission, positioning and growth factor receptor regulations. Proposed roles for ER-endosome MCS in lipid transport and Ca2 + signalling