The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
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DOI：
10.1007/s00424-003-1028-9
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发表时间：
2003-06-01
影响因子：
4.5
通讯作者：
Vriens, J
中科院分区：
文献类型：
--
作者：
Nilius, B;Watanabe, H;Vriens, J
瞬时受体电位（TRP）通道提供了一个巨大的可变性的Ca2+内流机制触发了广泛的刺激。在这篇综述中，我们讨论了香草素亚家族TRPV4的Ca 2+和Mg 2+渗透性TRP通道的激活特性。该通道被各种物理和化学刺激激活，例如细胞肿胀、热、磷酸盐，并且可能被能够诱导Ca2+进入的内源性配体激活。对这一渠道的监管知之甚少。我们将仅提及TRPV4的Ca2+依赖性抑制机制。该通道可能的功能作用将与其观察到的表达模式相关。最后，我们讨论了TRPV4通道功能的结构决定因素。
Transient receptor potential (TRP) channels provide an enormous variability of Ca2+ influx mechanisms triggered by a wide range of stimuli. In this review, we discuss the activation properties of the Ca2+- and Mg2+-permeable TRP channel of the vanilloid subfamily TRPV4. This channel is activated by various physical and chemical stimuli, such as cell swelling, heat, phorbols and, probably, by endogenous ligands, which are able to induce Ca2+ entry. Not much is known about the regulation of this channel. We will refer only to a mechanism of Ca2+-dependent inhibition of TRPV4. Possible functional roles of this channel will be correlated with its observed expression pattern. Finally, we discuss the structural determinants of TRPV4 channel function.