SYNTHESIS OF C-FUNCTIONALIZED AND N-FUNCTIONALIZED DERIVATIVES OF 1,4,7-TRIAZACYCLONONANE-1,4,7-TRIYLTRIACETIC ACID (NOTA), 1,4,7,10-TETRA-AZACYCLODODECANE-1,4,7,10-TETRAYLTETRA-ACETIC ACID (DOTA), AND DIETHYLENENETRIAMINEPENTA-ACETIC ACID (DTPA) - BIFUNCTIONAL COMPLEXING AGENTS FOR THE DERIVATIZATION OF ANTIBODIES
SYNTHESIS OF C-FUNCTIONALIZED AND N-FUNCTIONALIZED DERIVATIVES OF 1,4,7-TRIAZACYCLONONANE-1,4,7-TRIYLTRIACETIC ACID (NOTA), 1,4,7,10-TETRA-AZACYCLODODECANE-1,4,7,10-TETRAYLTETRA-ACETIC ACID (DOTA), AND DIETHYLENENETRIAMINEPENTA-ACETIC ACID (DTPA) - BIFUNCTIONAL COMPLEXING AGENTS FOR THE DERIVATIZATION OF ANTIBODIES
复制标题
DOI：
10.1039/p19900002567
复制
发表时间：
1990-09-01
期刊：
影响因子：
--
通讯作者：
BOYCE, BA
中科院分区：
文献类型：
--
作者：
COX, JPL;CRAIG, AS;BOYCE, BA
以(2S)-赖氨酸为前体，合成了1,4,7-三氮杂环壬烷、1,4,7,10-四氮杂环十二烷和3-氮杂戊烷-1,5-二胺的氨基丁基衍生物。描述了向反应性马来酰亚胺衍生物的转化，并定义了涉及氮官能化的标题络合剂的合成替代策略。
Using (2S)-lysine as a precursor, the syntheses of aminobutyl derivatives of 1,4,7-triazacyclononane, 1,4,7,10-tetra-azacyclododecane, and 3-azapentane-1,5-diamine are described. Transformation into their reactive maleimide derivatives is described and alternative strategies for synthesizing the title complexing agents involving nitrogen functionalization are defined.