Effects of citalopram treatment on hypothermic and hormonal responses to the 5-HT1A receptor agonist buspirone in patients with major depression and therapeutic response
Effects of citalopram treatment on hypothermic and hormonal responses to the 5-HT1A receptor agonist buspirone in patients with major depression and therapeutic response
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DOI：
10.1016/j.psyneuen.2007.01.006
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发表时间：
2007-05-01
影响因子：
3.7
通讯作者：
Gasto, Cristobal
中科院分区：
文献类型：
--
作者：
Navines, Ricard;Martin-Santos, Rocio;Gasto, Cristobal
5-羟色胺（5-HT） 5-HT1A受体似乎在重度抑郁症的病理生理和抗抑郁药的作用机制中发挥重要作用。5HT（1A）受体的体内功能可以通过特定的药理学激发试验来监测。本研究旨在探讨抑郁症患者服用西酞普兰8周前后5-HT1A受体的适应性变化。研究人群包括30名年龄在18-45岁、患有重度抑郁症（DSM-IV）的连续门诊患者。基底。汉密尔顿抑郁评定量表（HRSD）得分均在17分以上。治疗反应定义为HRSD评分降低50%。测定5-HT1A受体激动剂丁螺环酮（30mg PO）诱导的低温和内分泌反应（ACTH、皮质醇和催乳素）。服用西酞普兰8周后，丁螺环酮引起的低温反应三角max明显降低（p < 0.001）。患者对ACTH（三角形max p = 0.005; AUC p = 0.028）和皮质醇的反应下降。（三角形Max p = 0.05）。然而，催乳素反应增加（三角max p = 0.02; AUC p = 0.005）。治疗效果与ACTH （r = 0.883; p < 0.001）和皮质醇的降低有显著相关性。（r = 0.610; p = 0.001）。西酞普兰引起的改变支持重性抑郁症中5-HT1A受体的改变。下丘脑轴过度活动的减少可能是与西酞普兰反应相关的一个因素。(C) 2007 Elsevier Ltd.版权所有。
Serotonin (5-HT) 5-HT1A receptor seems to play an important role in the pathophysiology of major depression and in the mechanism of action of antidepressants. In vivo function of 5HT(1A) receptors can be monitored using specific pharmacological challenge tests. The present study aimed at exploring the adaptative 5-HT1A receptor changes in depressed patients before and after 8 week treatment with citalopram. The study population consisted of 30 consecutive outpatients of both sexes aged 18-45 years with major depressive disorders (DSM-IV). Basal. score in the Hamilton Rating Scale for Depression (HRSD) was higher than 17. Therapeutic response was defined as a 50% decrease in the HRSD score. The hypothermic and endocrine responses (ACTH, cortisol, and prolactin) induced by the 5-HT1A receptor agonist, buspirone (30mg PO) were measured. After 8 weeks on citalopram, the triangle max of hypothermic response elicited by buspirone was markedly decreased (p < 0.001). Patients showed a decrease in responses to ACTH (triangle max p = 0.005; AUC p = 0.028) and cortisol. (triangle max p = 0.05). However, the prolactin response increased (triangle max p = 0.02; AUC p = 0.005). There was a significant correlation between the therapeutic effect and reductions of ACTH (r = 0.883; p < 0.001) and cortisol. (r = 0.610; p = 0.001) responses. Changes induced by citalopram support an alteration of 5-HT1A receptors in major depression. A decrease in the overactivity of the HPA axis may be one factor associated with the response to citalopram. (C) 2007 Elsevier Ltd. All rights reserved.