Role of Spatial Averaging in the Precision of Gene Expression Patterns
Role of Spatial Averaging in the Precision of Gene Expression Patterns
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DOI：
10.1103/physrevlett.103.258101
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发表时间：
2009-12-18
影响因子：
8.6
通讯作者：
ten Wolde, Pieter Rein
中科院分区：
文献类型：
--
作者：
Erdmann, Thorsten;Howard, Martin;ten Wolde, Pieter Rein
在胚胎发育过程中，分化细胞通过基因表达响应来自形态梯度的位置线索。虽然基因表达常常极不稳定，但胚胎发育是精确的。我们通过理论和模拟表明，表达蛋白的扩散可以提高其表达域的精度。虽然扩散降低了表达边界的清晰度，但它也通过洗掉基因表达的爆发来减少超级泊松噪声。平衡这些影响产生一个最佳的扩散常数，最大限度地提高表达域的精度。
During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryonic development is precise. We show by theory and simulations that diffusion of the expressed protein can enhance the precision of its expression domain. While diffusion lessens the sharpness of the expression boundary, it also reduces super-Poissonian noise by washing out bursts of gene expression. Balancing these effects yields an optimal diffusion constant maximizing the precision of the expression domain.