The effects of maternal brucellosis on pregnancy outcome
The effects of maternal brucellosis on pregnancy outcome
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DOI：
10.3855/jidc.268
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发表时间：
2008-06-01
影响因子：
1.9
通讯作者：
Ahmed, Amien, I
中科院分区：
文献类型：
--
作者：
Elshamy, Maged;Ahmed, Amien, I
背景：我们的目的是评估布鲁氏菌感染并发妊娠的结果。设计：前瞻性研究。地点：沙特阿拉伯 TAIF 的 EL-Hasan 国立医院、El-Rawad 诊所（研究的实践部分在此完成）和曼苏拉大学医院妇产科（研究的理论部分在此完成）。方法：本研究于 2005 年 8 月至 12 月进行2007年，对450名孕妇进行布病抗体滴度管法检测； 415 人没有布鲁氏菌病症状或体征，35 人有该疾病的症状和体征。 55 名孕妇（第 1 组）的抗体滴度呈阳性，395 名孕妇（第 2 组）的抗体滴度呈阴性。两组均在妊娠期和新生儿期进行随访，以确定是否有任何类型的生殖障碍。结果：研究中孕妇的布鲁氏菌病发病率为 12.2%。 I组流产发生率为27.27%； IUFD为12.72%；早产率为10.90%。试验组和对照组之间的流产率和宫内节育率有统计学显着性差异，但早产率没有显着性差异。滴度大于1/160的患者与滴度小于1/160的患者流产率差异有统计学意义（p=0.03）。结论：布鲁氏菌病患者流产率较高。建议对布病流行地区保持高度警惕。
Background: Our aim was to assess the outcome of pregnancies complicated by Brucella infection.Design: Prospective study.Setting: EL-Hasan National Hospital, El-Rawad Clinic, TAIF, SAUDI ARABIA (where the practical part of the study was accomplished) and Obstetrics & Gynecology Department, Mansoura University Hospital (where the theoretical part of the study was completed).Methods: This study was conducted from August 2005 to December 2007. Tube method for detection of antibody titre for brucellosis was performed on 450 pregnant women; 415 had no symptoms or signs of brucellosis and 35 had symptoms and signs of the disease. The antibody titre was positive in 55 pregnant women (group 1) and negative in 395 pregnant women (group 2). Both groups were followed up during pregnancy and the neonatal period to determine any type of reproductive failure.Results: The incidence of brucellosis was 12.2% among pregnant women included in the study. The incidence of abortion in group I was 27.27%; IUFD was 12.72%; and preterm labour was 10.90%. There were statistically significant differences in the abortion and IUFD rates but no significant difference in the preterm labour rates between the test and control groups. There was a statistically significant difference in abortion rates between patients with a titre more than 1/160 and those with a titre less than 1/160 (p=0.03).Conclusion: The frequency of fetal loss among patients with brucellosis is very high. It is advisable to have a high degree of alertness for brucellosis in endemic areas.