EGF receptor-targeted nanocarriers for enhanced cancer treatment.
EGF receptor-targeted nanocarriers for enhanced cancer treatment.
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DOI：
10.2217/nnm.12.160
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Sen Gupta A
中科院分区：
文献类型：
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作者：
Master AM;Sen Gupta A
“纳米医学”方法通过将治疗药物包裹在工程纳米载体中，彻底改变了癌症治疗。这些纳米载体能够在肿瘤基质中特异性聚集，然后被癌细胞内化，从而实现位点选择性作用，同时将非特异性摄取和有害副作用降至最低。纳米载体能够被动渗透肿瘤的渗漏血管，从而实现在肿瘤基质中的特异性聚集，而细胞内化通常是通过利用受体介导的主动内吞机制实现的，即在载体表面修饰受体特异性配体。为此，在多种癌症中发现的一种非常重要的受体是表皮生长因子受体（EGF受体），它与肿瘤的侵袭和增殖有关。在此背景下，我们全面综述了在纳米载体上修饰配体以主动靶向EGF受体的各种方法，并讨论了它们在优化EGF受体靶向纳米医学系统设计方面的优缺点。
The ‘nanomedicine’ approach has revolutionized cancer therapy by enabling the packaging of therapeutic agents within engineered nanovehicles that can specifically accumulate within the tumor stroma and then be internalized within cancer cells, to render site-selective action while minimizing nonspecific uptake and harmful side effects. While the specific accumulation within the tumor stroma is rendered by the ability of the nanovehicles to passively permeate through the tumor’s leaky vasculature, the cellular internalization is often achieved by exploiting receptor-mediated active endocytotic mechanisms using receptor-specific ligand decoration on the vehicle surface. To this end, a highly important receptor found in several cancers is the EGF receptor, which has been implicated in tumor aggression and proliferation. In this context, we provide a comprehensive review of the various approaches of ligand decorations on nanovehicles for active targeting to EGF receptors, and discuss their pros and cons towards optimizing the design of EGF receptor-targeted nanomedicine systems.