Fetal origins of adult disease.
Fetal origins of adult disease.
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DOI：
10.1016/j.cppeds.2011.01.001
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发表时间：
2011-07
影响因子：
1.6
通讯作者：
Devaskar SU
中科院分区：
文献类型：
--
作者：
Calkins K;Devaskar SU
David Barker 博士首先普及了成人疾病胎儿起源（FOAD）的概念。自成立以来，FOAD 就受到了广泛关注。 FOAD 假说认为，早期发育过程中的事件对一个人未来患成人疾病的风险具有深远的影响。低出生体重是胎儿生长和营养不良的替代标志，与冠状动脉疾病、高血压、肥胖和胰岛素抵抗有关。线索最初来自 20 世纪欧洲的大型出生登记处。如今，大量不同的人类群体和各种动物模型已经广泛复制了这些原始观察结果。本综述将重点关注与 FOAD 相关的发病机制，并探讨 David Barker 博士的里程碑式研究以及其他人类和动物模型数据。 FOAD 的影响不仅限于低出生体重人群，还包括在不同的关键发育时期面临营养和非营养压力的婴儿，最终导致疾病状态。通过了解 FOAD，医疗保健专业人员和政策制定者将把这个问题作为医疗保健的高度优先事项，并对慢性病高风险人群实施预防措施和治疗。
Dr. David Barker first popularized the concept of fetal origins of adult disease (FOAD). Since its inception, FOAD has received considerable attention. The FOAD hypothesis holds that events during early development have a profound impact on one’s risk for development of future adult disease. Low birth weight, a surrogate marker of poor fetal growth and nutrition, is linked to coronary artery disease, hypertension, obesity, and insulin resistance. Clues originally arose from large 20th century, European birth registries. Today, large, diverse human cohorts and various animal models have extensively replicated these original observations. This review will focus on the pathogenesis related to FOAD and examines Dr. David Barker’s landmark studies, along with additional human and animal model data. Implications of the FOAD extend beyond the low birth weight population and include babies exposed to stress, both nutritional and non-nutritional, during different critical periods of development, which ultimately result in a disease state. By understanding FOAD, health care professionals and policy makers will make this issue a high healthcare priority and implement preventative measures and treatment for those at higher risk for chronic diseases.