An actin-binding protein Espin is a novel growth regulator for melanoma.
An actin-binding protein Espin is a novel growth regulator for melanoma.
复制标题
肌动蛋白结合蛋白 Espin 是一种新型黑色素瘤生长调节剂。
DOI：
10.1038/jid.2014.249
复制
发表时间：
2014
影响因子：
6.5
通讯作者：
Kato M.
中科院分区：
文献类型：
--
作者：
Yanagishita T;Yajima I;Kumasaka MY;Iida M;Xiang L;Tamada Y;Mtsuoto Y;Watabnabe D;Kato M.
尽管黑色素瘤的发病率以比任何其他癌症更高的速率增加，但其有效疗法是有限的（Chen等人，1996年）的报告。鉴定调节黑色素瘤生长、进展和转移的关键分子对于提供新的治疗策略至关重要。我们先前开发了RET转基因小鼠品系304/B6，其携带在金属硫蛋白-I启动子调控下的致癌RET（RFP/RET
Effective therapies for melanoma are limited despite the fact that the incidence is increasing at a greater rate than that of any other cancers (Chen et al., 1996). Identification of key molecules regulating growth, progression, and metastasis in melanoma is essential to provide novel therapeutic strategies. We previously developed RET-transgenic mice of line 304/B6 carrying oncogenic RET (RFP/RET) under regulation of the metallothionein-I promoter