The isolation, structural determination, and total synthesis of terfestatin A, a novel auxin signaling inhibitor from Streptomyces sp.
The isolation, structural determination, and total synthesis of terfestatin A, a novel auxin signaling inhibitor from Streptomyces sp.
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DOI：
10.1016/j.tetlet.2004.09.055
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发表时间：
2004-11-01
影响因子：
1.8
通讯作者：
Nozaki, H
中科院分区：
文献类型：
--
作者：
Yamazoe, A;Hayashi, K;Nozaki, H
吲哚3-乙酸是一种植物激素生长素，调节植物生长发育的方方面面。在利用含有生长素反应报告基因的转基因拟南芥中筛选生长素信号的特异性抑制剂时，terfestatin A被发现是一种新的链霉菌生长素信号的抑制剂。F40。经光谱分析、化学降解和全合成，确定其结构为对三苯基β-葡萄糖苷。(C)2004爱思唯尔有限公司。保留所有权利。
Indole 3-acetic acid, a plant hormone auxin, regulates every aspects of plant growth and development. In the screening for specific inhibitors on auxin signaling using the transgenic Arabidopsis plant harboring the auxin-responsive reporter gene, terfestatin A was found to be a novel inhibitor of auxin signaling from the culture of Streptomyces sp. F40. The structure of terfestatin A was determined to be p-terphenyl beta-glucoside on the basis of spectroscopic analyses, chemical degradation, and total synthesis. (C) 2004 Elsevier Ltd. All rights reserved.