Antidiabetic and Antioxidant Effects of Oleanolic Acid from Ligustrum lucidum Ait in Alloxan-induced Diabetic Rats
Antidiabetic and Antioxidant Effects of Oleanolic Acid from Ligustrum lucidum Ait in Alloxan-induced Diabetic Rats
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DOI：
10.1002/ptr.2603
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发表时间：
2009-09-01
影响因子：
7.2
通讯作者：
Han, Zengsheng
中科院分区：
文献类型：
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作者：
Gao, Dawei;Li, Qingwang;Han, Zengsheng
研究女贞子齐墩果酸（OA）对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病和抗氧化作用。四氧嘧啶诱导的糖尿病大鼠（剂量分别为60和100 mg/kg，持续40天）的OA表现出明显的降糖活性。糖尿病大鼠血清总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-c）水平均低于对照组，高密度脂蛋白胆固醇（HDL-c）水平高于对照组。OA治疗后，糖尿病大鼠血清中谷草转氨酶（AST）、丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）水平显著降低。此外，OA降低了糖尿病大鼠肝脏和肾脏丙二醛（MDA）水平，升高了超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-px）活性。上述结果表明，OA可避免四氧嘧啶引起的肝功能损伤；对糖尿病大鼠具有降血糖、降血脂和抗氧化作用。OA的抗氧化能力可能是其降糖降血脂作用的机制之一。版权所有2009 John Wiley & Sons， Ltd。
The present study evaluated the antidiabetic and antioxidant effects of oleanolic acid (OA) from Ligustrum lucidum Ait (LLA) in alloxan-induced diabetic rats. OA in the alloxan-induced diabetic rats showed significant hypoglycemic activity by lowering blood glucose (at doses of 60 and 100 mg/kg for 40 days). The levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-c) in the OA-treated diabetic rats were lower, and the high-density lipoprotein cholesterol (HDL-c) level was higher than in the control diabetic rats. A significant reduction in the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels of diabetic rats following OA treatment was also observed. Furthermore, OA treatment decreased the malondialdehyde (MDA) level, but increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities of the liver and kidney in diabetic rats. These results indicate that OA could protect the liver function avoiding alloxan-induced damage; OA had hypoglycemic, hypolipidemic and antioxidant efficacy in the diabetic rats. The antioxidant ability of OA might be one of the mechanisms of its hypoglycemic and hypolipidemic effects. Copyright (c) 2009 John Wiley & Sons, Ltd.